Synergistic Interactions between the Hypomethylating Agent Thio-Deoxycytidine and Venetoclax in Myelodysplastic Syndrome Cells

Synergistic Interactions between the Hypomethylating Agent Thio-Deoxycytidine and Venetoclax in Myelodysplastic Syndrome Cells

Interactions between the novel hypomethylating agent (HMA) thio-deoxycytidine (T-dCyd) and the BCL-2 antagonist ABT-199 (venetoclax) have been examined in human myelodysplastic syndrome (MDS) cells. The cells were exposed to agents alone or in combination, after which apoptosis was assessed, and a W...

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Bibliographic Details
Main Authors: Xiaoyan Hu, Lin Li, Jewel Nkwocha, Kanika Sharma, Liang Zhou, Steven Grant
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Hematology Reports
Subjects:
T-dCyd
ABT-199/venetoclax
myelodysplastic syndrome
ROS
Online Access:https://www.mdpi.com/2038-8330/15/1/10

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