Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
Children undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug inte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-01-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X20981548 |
| _version_ | 1818388539052654592 |
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| author | Melanie Dubois MD Avika Dixit MBBS, MPH, MBI Gabriella Lamb MD, MPH |
| author_facet | Melanie Dubois MD Avika Dixit MBBS, MPH, MBI Gabriella Lamb MD, MPH |
| author_sort | Melanie Dubois MD |
| collection | DOAJ |
| description | Children undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug interactions. There are limited data that address the unique challenges for the management of TB in the pediatric transplant population. This review presents the current understanding of the epidemiology, clinical presentation, diagnosis, management, and prevention for pediatric transplant recipients with TB infection and disease. Further studies are needed to improve diagnosis of TB and optimize treatment outcomes for these patients. |
| first_indexed | 2024-12-14T04:27:26Z |
| format | Article |
| id | doaj.art-055cf28028f94d0e8113499c9980d59b |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-14T04:27:26Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-055cf28028f94d0e8113499c9980d59b2022-12-21T23:17:09ZengSAGE PublishingGlobal Pediatric Health2333-794X2021-01-01810.1177/2333794X20981548Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell RecipientsMelanie Dubois MD0Avika Dixit MBBS, MPH, MBI1Gabriella Lamb MD, MPH2Harvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAChildren undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug interactions. There are limited data that address the unique challenges for the management of TB in the pediatric transplant population. This review presents the current understanding of the epidemiology, clinical presentation, diagnosis, management, and prevention for pediatric transplant recipients with TB infection and disease. Further studies are needed to improve diagnosis of TB and optimize treatment outcomes for these patients.https://doi.org/10.1177/2333794X20981548 |
| spellingShingle | Melanie Dubois MD Avika Dixit MBBS, MPH, MBI Gabriella Lamb MD, MPH Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients Global Pediatric Health |
| title | Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients |
| title_full | Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients |
| title_fullStr | Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients |
| title_full_unstemmed | Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients |
| title_short | Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients |
| title_sort | tuberculosis in pediatric solid organ and hematopoietic stem cell recipients |
| url | https://doi.org/10.1177/2333794X20981548 |
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