Copper-catalyzed N-arylation of bis(indolyl)methanes: the first approach for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction
This investigation describes an efficient method for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction of unsubstituted bis(indolyl)methanes with aryl iodides in the presence of several Cu salts and CuFe$_{2}$O$_{4}$ as homogeneous and heterogeneous catalysts,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2021-09-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.111/ |
| Summary: | This investigation describes an efficient method for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction of unsubstituted bis(indolyl)methanes with aryl iodides in the presence of several Cu salts and CuFe$_{2}$O$_{4}$ as homogeneous and heterogeneous catalysts, respectively. Among these Cu containing catalysts, CuFe$_{2}$O$_{4}$ under ligand-free conditions showed the best activity and selectivity for mono N-arylation of bis(indolyl)methanes. Notably, CuFe$_{2}$O$_{4}$ catalyst was recovered and reused several times. |
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| ISSN: | 1878-1543 |