The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer
Colorectal cancer (CRC) is a lethal malignancy worldwide. Exosomes are extracellular vesicles derived from the endosomal pathway of nearly all cells and can be found in body fluids. They can be considered an intercellular system in the human body that can mediate near- and long-distance intercellula...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-11-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811302 |
| _version_ | 1797400702335582208 |
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| author | Jinhong Han Shuai Ma Yao Zhao Bingxian Wang Shuang Ding Yuhan Hu |
| author_facet | Jinhong Han Shuai Ma Yao Zhao Bingxian Wang Shuang Ding Yuhan Hu |
| author_sort | Jinhong Han |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a lethal malignancy worldwide. Exosomes are extracellular vesicles derived from the endosomal pathway of nearly all cells and can be found in body fluids. They can be considered an intercellular system in the human body that can mediate near- and long-distance intercellular communication due to their features and functions. Investigations have revealed that exosomes are participated in different processes, physiologically and pathologically, especially in cancer. However, the clinical value of exosomes and their mechanisms of action in CRC are unclear and have not been systematically assessed. The purpose of this review is to discuss how exosomes play a role in the occurrence and development of CRC, with a particular focus on the functions and underlying mechanisms of tumor-derived exosomes as well as non-tumor-derived exosomes. We also describe the evidence that exosomes can be used as diagnostic and prognostic markers for CRC. In addition, the possibilities of exosomes in CRC clinical transformation are also discussed. |
| first_indexed | 2024-03-09T01:59:19Z |
| format | Article |
| id | doaj.art-055e0cb5e0764ea98f4f7c1ebd0ccfa7 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-09T01:59:19Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-055e0cb5e0764ea98f4f7c1ebd0ccfa72023-12-08T07:49:20ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-11-01281130210.31083/j.fbl2811302S2768-6701(23)00924-3The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal CancerJinhong Han0Shuai Ma1Yao Zhao2Bingxian Wang3Shuang Ding4Yuhan Hu5Department of Human Anatomy and Histology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, ChinaColorectal cancer (CRC) is a lethal malignancy worldwide. Exosomes are extracellular vesicles derived from the endosomal pathway of nearly all cells and can be found in body fluids. They can be considered an intercellular system in the human body that can mediate near- and long-distance intercellular communication due to their features and functions. Investigations have revealed that exosomes are participated in different processes, physiologically and pathologically, especially in cancer. However, the clinical value of exosomes and their mechanisms of action in CRC are unclear and have not been systematically assessed. The purpose of this review is to discuss how exosomes play a role in the occurrence and development of CRC, with a particular focus on the functions and underlying mechanisms of tumor-derived exosomes as well as non-tumor-derived exosomes. We also describe the evidence that exosomes can be used as diagnostic and prognostic markers for CRC. In addition, the possibilities of exosomes in CRC clinical transformation are also discussed.https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811302colorectal cancerexosomebiomarkerdiagnosisclinical transformation |
| spellingShingle | Jinhong Han Shuai Ma Yao Zhao Bingxian Wang Shuang Ding Yuhan Hu The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer Frontiers in Bioscience-Landmark colorectal cancer exosome biomarker diagnosis clinical transformation |
| title | The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer |
| title_full | The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer |
| title_fullStr | The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer |
| title_full_unstemmed | The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer |
| title_short | The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer |
| title_sort | function underlying mechanism and clinical potential of exosomes in colorectal cancer |
| topic | colorectal cancer exosome biomarker diagnosis clinical transformation |
| url | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811302 |
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