Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer
Abstract Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chine...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-019-1086-x |
| _version_ | 1818452668822061056 |
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| author | Jiang Liu Li Tang Jinhua Yi Guimei Li Youwang Lu Yu Xu Shuhua Zhao Rui Mao Xiaolu Li Li Ren Kunhua Wang |
| author_facet | Jiang Liu Li Tang Jinhua Yi Guimei Li Youwang Lu Yu Xu Shuhua Zhao Rui Mao Xiaolu Li Li Ren Kunhua Wang |
| author_sort | Jiang Liu |
| collection | DOAJ |
| description | Abstract Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features. Results A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (≤49 years of age), female sex, and proximal tumour location. Conclusions This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis. |
| first_indexed | 2024-12-14T21:26:45Z |
| format | Article |
| id | doaj.art-055e12da3bbd4793874516aef07295a6 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-14T21:26:45Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-055e12da3bbd4793874516aef07295a62022-12-21T22:46:47ZengBMCBMC Gastroenterology1471-230X2019-11-0119111010.1186/s12876-019-1086-xUnique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancerJiang Liu0Li Tang1Jinhua Yi2Guimei Li3Youwang Lu4Yu Xu5Shuhua Zhao6Rui Mao7Xiaolu Li8Li Ren9Kunhua Wang10Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical UniversityDepartment of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical UniversityDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive DiseasePublic Technical Service Center, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical UniversityDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive DiseaseDepartment of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical UniversitySchool of Stomatology, Kunming Medical UniversityPublic Technical Service Center, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Reproductive Gynecology, the First People’s Hospital of Yunnan ProvinceDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive DiseaseAbstract Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features. Results A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (≤49 years of age), female sex, and proximal tumour location. Conclusions This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis.http://link.springer.com/article/10.1186/s12876-019-1086-xColorectal cancerCpG island methylator phenotypeCIMPBRAF mutationsKRAS mutations |
| spellingShingle | Jiang Liu Li Tang Jinhua Yi Guimei Li Youwang Lu Yu Xu Shuhua Zhao Rui Mao Xiaolu Li Li Ren Kunhua Wang Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer BMC Gastroenterology Colorectal cancer CpG island methylator phenotype CIMP BRAF mutations KRAS mutations |
| title | Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer |
| title_full | Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer |
| title_fullStr | Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer |
| title_full_unstemmed | Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer |
| title_short | Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer |
| title_sort | unique characteristics of cpg island methylator phenotype cimp in a chinese population with colorectal cancer |
| topic | Colorectal cancer CpG island methylator phenotype CIMP BRAF mutations KRAS mutations |
| url | http://link.springer.com/article/10.1186/s12876-019-1086-x |
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