Dose Profile Modulation of Proton Minibeam for Clinical Application
The feasibility of proton minibeam radiation therapy (pMBRT) using a multislit collimator (MSC) and a scattering device was evaluated for clinical use at a clinical proton therapy facility. We fabricated, through Monte Carlo (MC) simulations, not only an MSC with a high peak-to-valley dose ratio (PV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/12/2888 |
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| author | Myeongsoo Kim Ui-Jung Hwang Kyeongyun Park Dohyeon Kim Hak Soo Kim Sang Hyoun Choi Jong Hwi Jeong Dongho Shin Se Byeong Lee Joo-Young Kim Tae Hyun Kim Hye Jung Baek Hojin Kim Kihwan Kim Sang Soo Kim Young Kyung Lim |
| author_facet | Myeongsoo Kim Ui-Jung Hwang Kyeongyun Park Dohyeon Kim Hak Soo Kim Sang Hyoun Choi Jong Hwi Jeong Dongho Shin Se Byeong Lee Joo-Young Kim Tae Hyun Kim Hye Jung Baek Hojin Kim Kihwan Kim Sang Soo Kim Young Kyung Lim |
| author_sort | Myeongsoo Kim |
| collection | DOAJ |
| description | The feasibility of proton minibeam radiation therapy (pMBRT) using a multislit collimator (MSC) and a scattering device was evaluated for clinical use at a clinical proton therapy facility. We fabricated, through Monte Carlo (MC) simulations, not only an MSC with a high peak-to-valley dose ratio (PVDR) at the entrance of the proton beam, to prevent radiation toxicity, but also a scattering device to modulate the PVDR in depth. The slit width and center-to-center distance of the diverging MSC were 2.5 mm and 5.0 mm at the large end, respectively, and its thickness and available field size were 100 mm and 76 × 77.5 mm<sup>2</sup>, respectively. Spatially fractionated dose distributions were measured at various depths using radiochromic EBT3 films and also tested on bacterial cells. MC simulation showed that the thicker the MSC, the higher the PVDR at the phantom surface. Dosimetric evaluations showed that lateral dose profiles varied according to the scatterer’s thickness, and the depths satisfying PVDR = 1.1 moved toward the surface as their thickness increased. The response of the bacterial cells to the proton minibeams’ depth was also established, in a manner similar to the dosimetric pattern. Conclusively, these results strongly suggest that pMBRT can be implemented in clinical centers by using MSC and scatterers. |
| first_indexed | 2024-03-10T00:12:40Z |
| format | Article |
| id | doaj.art-055eecaf01ad44638a613a3d652b98f1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:12:40Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-055eecaf01ad44638a613a3d652b98f12023-11-23T15:55:53ZengMDPI AGCancers2072-66942022-06-011412288810.3390/cancers14122888Dose Profile Modulation of Proton Minibeam for Clinical ApplicationMyeongsoo Kim0Ui-Jung Hwang1Kyeongyun Park2Dohyeon Kim3Hak Soo Kim4Sang Hyoun Choi5Jong Hwi Jeong6Dongho Shin7Se Byeong Lee8Joo-Young Kim9Tae Hyun Kim10Hye Jung Baek11Hojin Kim12Kihwan Kim13Sang Soo Kim14Young Kyung Lim15Department of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Korea Cancer Center Hospital, Seoul 01812, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaRadiological Science Branch, Research Institute, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaRadiological Science Branch, Research Institute, National Cancer Center, Goyang 10408, KoreaDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, KoreaThe feasibility of proton minibeam radiation therapy (pMBRT) using a multislit collimator (MSC) and a scattering device was evaluated for clinical use at a clinical proton therapy facility. We fabricated, through Monte Carlo (MC) simulations, not only an MSC with a high peak-to-valley dose ratio (PVDR) at the entrance of the proton beam, to prevent radiation toxicity, but also a scattering device to modulate the PVDR in depth. The slit width and center-to-center distance of the diverging MSC were 2.5 mm and 5.0 mm at the large end, respectively, and its thickness and available field size were 100 mm and 76 × 77.5 mm<sup>2</sup>, respectively. Spatially fractionated dose distributions were measured at various depths using radiochromic EBT3 films and also tested on bacterial cells. MC simulation showed that the thicker the MSC, the higher the PVDR at the phantom surface. Dosimetric evaluations showed that lateral dose profiles varied according to the scatterer’s thickness, and the depths satisfying PVDR = 1.1 moved toward the surface as their thickness increased. The response of the bacterial cells to the proton minibeams’ depth was also established, in a manner similar to the dosimetric pattern. Conclusively, these results strongly suggest that pMBRT can be implemented in clinical centers by using MSC and scatterers.https://www.mdpi.com/2072-6694/14/12/2888spatially fractionated radiation therapyproton therapyproton minibeam radiation therapymultislit collimatorscattererpeak-to-valley dose ratio |
| spellingShingle | Myeongsoo Kim Ui-Jung Hwang Kyeongyun Park Dohyeon Kim Hak Soo Kim Sang Hyoun Choi Jong Hwi Jeong Dongho Shin Se Byeong Lee Joo-Young Kim Tae Hyun Kim Hye Jung Baek Hojin Kim Kihwan Kim Sang Soo Kim Young Kyung Lim Dose Profile Modulation of Proton Minibeam for Clinical Application Cancers spatially fractionated radiation therapy proton therapy proton minibeam radiation therapy multislit collimator scatterer peak-to-valley dose ratio |
| title | Dose Profile Modulation of Proton Minibeam for Clinical Application |
| title_full | Dose Profile Modulation of Proton Minibeam for Clinical Application |
| title_fullStr | Dose Profile Modulation of Proton Minibeam for Clinical Application |
| title_full_unstemmed | Dose Profile Modulation of Proton Minibeam for Clinical Application |
| title_short | Dose Profile Modulation of Proton Minibeam for Clinical Application |
| title_sort | dose profile modulation of proton minibeam for clinical application |
| topic | spatially fractionated radiation therapy proton therapy proton minibeam radiation therapy multislit collimator scatterer peak-to-valley dose ratio |
| url | https://www.mdpi.com/2072-6694/14/12/2888 |
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