Anesthesia and Alzheimer's: A review
As early as 1955, it was Bedford who provided description of cognitive changes in elderly patients following anesthesia and surgery. Reports of individuals with catastrophic, non-stroke-related decline in cognitive functions following anesthesia and surgery lead to a perception in the lay population...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2020;volume=36;issue=3;spage=297;epage=302;aulast=Sun |
| _version_ | 1819229608201945088 |
|---|---|
| author | Jeffrey Y Sun |
| author_facet | Jeffrey Y Sun |
| author_sort | Jeffrey Y Sun |
| collection | DOAJ |
| description | As early as 1955, it was Bedford who provided description of cognitive changes in elderly patients following anesthesia and surgery. Reports of individuals with catastrophic, non-stroke-related decline in cognitive functions following anesthesia and surgery lead to a perception in the lay population that anesthesia and surgery have the potential to greatly exaggerate the progression of dementia, particularly Alzheimer's disease (AD). There is a concern that anesthesia and surgery could cause irreversible impairment, leading to AD. This could also explain the accelerated decline in patients with mild cognitive impairment. We seek to explore the relevant literature to determine whether a correlation exists and then propose a possible pathophysiologic mechanism. |
| first_indexed | 2024-12-23T11:15:52Z |
| format | Article |
| id | doaj.art-055f03e62efe4964b4f104a20accd0a5 |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-23T11:15:52Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-055f03e62efe4964b4f104a20accd0a52022-12-21T17:49:12ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852020-01-0136329730210.4103/joacp.JOACP_118_19Anesthesia and Alzheimer's: A reviewJeffrey Y SunAs early as 1955, it was Bedford who provided description of cognitive changes in elderly patients following anesthesia and surgery. Reports of individuals with catastrophic, non-stroke-related decline in cognitive functions following anesthesia and surgery lead to a perception in the lay population that anesthesia and surgery have the potential to greatly exaggerate the progression of dementia, particularly Alzheimer's disease (AD). There is a concern that anesthesia and surgery could cause irreversible impairment, leading to AD. This could also explain the accelerated decline in patients with mild cognitive impairment. We seek to explore the relevant literature to determine whether a correlation exists and then propose a possible pathophysiologic mechanism.http://www.joacp.org/article.asp?issn=0970-9185;year=2020;volume=36;issue=3;spage=297;epage=302;aulast=Sunalzheimer's diseaseanesthesiabiomarkersmild cognitive impairmentregional |
| spellingShingle | Jeffrey Y Sun Anesthesia and Alzheimer's: A review Journal of Anaesthesiology Clinical Pharmacology alzheimer's disease anesthesia biomarkers mild cognitive impairment regional |
| title | Anesthesia and Alzheimer's: A review |
| title_full | Anesthesia and Alzheimer's: A review |
| title_fullStr | Anesthesia and Alzheimer's: A review |
| title_full_unstemmed | Anesthesia and Alzheimer's: A review |
| title_short | Anesthesia and Alzheimer's: A review |
| title_sort | anesthesia and alzheimer s a review |
| topic | alzheimer's disease anesthesia biomarkers mild cognitive impairment regional |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2020;volume=36;issue=3;spage=297;epage=302;aulast=Sun |
| work_keys_str_mv | AT jeffreyysun anesthesiaandalzheimersareview |