Extracellular Matrix Molecules Facilitating Vascular Biointegration
All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy. A range of biomolecules in the subendothelial space have been shown to play critical roles in local regulation of thrombosis, endothelial...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-08-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-4983/3/3/569 |
| _version_ | 1798040373586558976 |
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| author | Martin K.C. Ng Praveesuda Michael Anna Waterhouse Steven G. Wise |
| author_facet | Martin K.C. Ng Praveesuda Michael Anna Waterhouse Steven G. Wise |
| author_sort | Martin K.C. Ng |
| collection | DOAJ |
| description | All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy. A range of biomolecules in the subendothelial space have been shown to play critical roles in local regulation of thrombosis, endothelial growth and smooth muscle cell proliferation, making these attractive candidates for modulation of vascular device biointegration. However, classically used biomaterial coatings, such as fibronectin and laminin, modulate only one of these components; enhancing endothelial cell attachment, but also activating platelets and triggering thrombosis. This review examines a subset of extracellular matrix molecules that have demonstrated multi-faceted vascular compatibility and accordingly are promising candidates to improve the biointegration of vascular biomaterials. |
| first_indexed | 2024-04-11T22:06:44Z |
| format | Article |
| id | doaj.art-055f6c04da58462380d1bda70fca4f2a |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-11T22:06:44Z |
| publishDate | 2012-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-055f6c04da58462380d1bda70fca4f2a2022-12-22T04:00:42ZengMDPI AGJournal of Functional Biomaterials2079-49832012-08-013356958710.3390/jfb3030569Extracellular Matrix Molecules Facilitating Vascular BiointegrationMartin K.C. NgPraveesuda MichaelAnna WaterhouseSteven G. WiseAll vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy. A range of biomolecules in the subendothelial space have been shown to play critical roles in local regulation of thrombosis, endothelial growth and smooth muscle cell proliferation, making these attractive candidates for modulation of vascular device biointegration. However, classically used biomaterial coatings, such as fibronectin and laminin, modulate only one of these components; enhancing endothelial cell attachment, but also activating platelets and triggering thrombosis. This review examines a subset of extracellular matrix molecules that have demonstrated multi-faceted vascular compatibility and accordingly are promising candidates to improve the biointegration of vascular biomaterials.http://www.mdpi.com/2079-4983/3/3/569vascularbiointegrationtropoelastinfibrillin-1perlecanfibulin-5 |
| spellingShingle | Martin K.C. Ng Praveesuda Michael Anna Waterhouse Steven G. Wise Extracellular Matrix Molecules Facilitating Vascular Biointegration Journal of Functional Biomaterials vascular biointegration tropoelastin fibrillin-1 perlecan fibulin-5 |
| title | Extracellular Matrix Molecules Facilitating Vascular Biointegration |
| title_full | Extracellular Matrix Molecules Facilitating Vascular Biointegration |
| title_fullStr | Extracellular Matrix Molecules Facilitating Vascular Biointegration |
| title_full_unstemmed | Extracellular Matrix Molecules Facilitating Vascular Biointegration |
| title_short | Extracellular Matrix Molecules Facilitating Vascular Biointegration |
| title_sort | extracellular matrix molecules facilitating vascular biointegration |
| topic | vascular biointegration tropoelastin fibrillin-1 perlecan fibulin-5 |
| url | http://www.mdpi.com/2079-4983/3/3/569 |
| work_keys_str_mv | AT martinkcng extracellularmatrixmoleculesfacilitatingvascularbiointegration AT praveesudamichael extracellularmatrixmoleculesfacilitatingvascularbiointegration AT annawaterhouse extracellularmatrixmoleculesfacilitatingvascularbiointegration AT stevengwise extracellularmatrixmoleculesfacilitatingvascularbiointegration |