The mutational signatures of formalin fixation on the human genome
Many archived tumour samples are stored as formalin-fixed and paraffin-embedded (FFPE) blocks, but this treatment can impact downstream genomics analyses. Here, the authors derive the mutational signatures of formalin on the cancer genome, and present FFPEsig, an algorithm that can distinguish and c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32041-5 |
| _version_ | 1811211450795950080 |
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| author | Qingli Guo Eszter Lakatos Ibrahim Al Bakir Kit Curtius Trevor A. Graham Ville Mustonen |
| author_facet | Qingli Guo Eszter Lakatos Ibrahim Al Bakir Kit Curtius Trevor A. Graham Ville Mustonen |
| author_sort | Qingli Guo |
| collection | DOAJ |
| description | Many archived tumour samples are stored as formalin-fixed and paraffin-embedded (FFPE) blocks, but this treatment can impact downstream genomics analyses. Here, the authors derive the mutational signatures of formalin on the cancer genome, and present FFPEsig, an algorithm that can distinguish and correct FFPE mutational signatures in archived cancer samples. |
| first_indexed | 2024-04-12T05:13:22Z |
| format | Article |
| id | doaj.art-055fce2179024c01b88e3328d1b634b1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T05:13:22Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-055fce2179024c01b88e3328d1b634b12022-12-22T03:46:41ZengNature PortfolioNature Communications2041-17232022-09-0113111410.1038/s41467-022-32041-5The mutational signatures of formalin fixation on the human genomeQingli Guo0Eszter Lakatos1Ibrahim Al Bakir2Kit Curtius3Trevor A. Graham4Ville Mustonen5Organismal and Evolutionary Biology Research Programme, Department of Computer Science, University of HelsinkiEvolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonEvolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonEvolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonEvolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonOrganismal and Evolutionary Biology Research Programme, Department of Computer Science, University of HelsinkiMany archived tumour samples are stored as formalin-fixed and paraffin-embedded (FFPE) blocks, but this treatment can impact downstream genomics analyses. Here, the authors derive the mutational signatures of formalin on the cancer genome, and present FFPEsig, an algorithm that can distinguish and correct FFPE mutational signatures in archived cancer samples.https://doi.org/10.1038/s41467-022-32041-5 |
| spellingShingle | Qingli Guo Eszter Lakatos Ibrahim Al Bakir Kit Curtius Trevor A. Graham Ville Mustonen The mutational signatures of formalin fixation on the human genome Nature Communications |
| title | The mutational signatures of formalin fixation on the human genome |
| title_full | The mutational signatures of formalin fixation on the human genome |
| title_fullStr | The mutational signatures of formalin fixation on the human genome |
| title_full_unstemmed | The mutational signatures of formalin fixation on the human genome |
| title_short | The mutational signatures of formalin fixation on the human genome |
| title_sort | mutational signatures of formalin fixation on the human genome |
| url | https://doi.org/10.1038/s41467-022-32041-5 |
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