Review of recent advances in managing periocular skin malignancies
Management of cutaneous malignancies can be particularly challenging when they are located in the periocular region. The standard of care for localized disease is complete surgical excision, but this may not be possible without significant disruption to visual structures and facial appearance. Defin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1275930/full |
| _version_ | 1827330777230082048 |
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| author | Daniel C. Trotier Daniel C. Trotier Leslie Huang Suzanne W. van Landingham Suzanne W. van Landingham Adam R. Burr Adam R. Burr Adam R. Burr Vincent T. Ma Vincent T. Ma Vincent T. Ma Vincent T. Ma |
| author_facet | Daniel C. Trotier Daniel C. Trotier Leslie Huang Suzanne W. van Landingham Suzanne W. van Landingham Adam R. Burr Adam R. Burr Adam R. Burr Vincent T. Ma Vincent T. Ma Vincent T. Ma Vincent T. Ma |
| author_sort | Daniel C. Trotier |
| collection | DOAJ |
| description | Management of cutaneous malignancies can be particularly challenging when they are located in the periocular region. The standard of care for localized disease is complete surgical excision, but this may not be possible without significant disruption to visual structures and facial appearance. Definitive radiation may be an option for some patients who cannot or do not wish to undergo surgery. Advances in systemic treatment options for locally advanced and metastatic skin cancers in the past 10 years have prompted investigation into neoadjuvant treatment of periocular cancers. The use of chemotherapy, immune checkpoint inhibitors, and targeted therapies have all been reported with varying degrees of success. For many patients, targeted therapies or immune checkpoint inhibitors should be considered depending on the cancer type, symptoms, and goals with the input of a multidisciplinary cancer care team. In this article, we systematically review the latest updates in surgical, radiotherapeutic, and medical management of periocular malignancies. |
| first_indexed | 2024-03-07T16:22:17Z |
| format | Article |
| id | doaj.art-056051d286024f5dad8deaf865f2ea0f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T16:22:17Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-056051d286024f5dad8deaf865f2ea0f2024-03-04T04:38:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.12759301275930Review of recent advances in managing periocular skin malignanciesDaniel C. Trotier0Daniel C. Trotier1Leslie Huang2Suzanne W. van Landingham3Suzanne W. van Landingham4Adam R. Burr5Adam R. Burr6Adam R. Burr7Vincent T. Ma8Vincent T. Ma9Vincent T. Ma10Vincent T. Ma11University of Wisconsin School of Medicine & Public Health, Madison, WI, United StatesDepartment of Medicine, Division of Hematology, Medical Oncology, and Palliative Care, University of Wisconsin-Madison, Madison, WI, United StatesUniversity of Wisconsin School of Medicine & Public Health, Madison, WI, United StatesUniversity of Wisconsin School of Medicine & Public Health, Madison, WI, United StatesDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United StatesUniversity of Wisconsin School of Medicine & Public Health, Madison, WI, United StatesDepartment of Human Oncology, University of Wisconsin-Madison, Madison, WI, United StatesUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United StatesUniversity of Wisconsin School of Medicine & Public Health, Madison, WI, United StatesDepartment of Medicine, Division of Hematology, Medical Oncology, and Palliative Care, University of Wisconsin-Madison, Madison, WI, United StatesUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI, United StatesManagement of cutaneous malignancies can be particularly challenging when they are located in the periocular region. The standard of care for localized disease is complete surgical excision, but this may not be possible without significant disruption to visual structures and facial appearance. Definitive radiation may be an option for some patients who cannot or do not wish to undergo surgery. Advances in systemic treatment options for locally advanced and metastatic skin cancers in the past 10 years have prompted investigation into neoadjuvant treatment of periocular cancers. The use of chemotherapy, immune checkpoint inhibitors, and targeted therapies have all been reported with varying degrees of success. For many patients, targeted therapies or immune checkpoint inhibitors should be considered depending on the cancer type, symptoms, and goals with the input of a multidisciplinary cancer care team. In this article, we systematically review the latest updates in surgical, radiotherapeutic, and medical management of periocular malignancies.https://www.frontiersin.org/articles/10.3389/fonc.2024.1275930/fullperiocular malignancycutaneous squamous cell carcinomabasal cell carcinomamelanomaMerkel cell carcinomasebaceous gland carcinoma |
| spellingShingle | Daniel C. Trotier Daniel C. Trotier Leslie Huang Suzanne W. van Landingham Suzanne W. van Landingham Adam R. Burr Adam R. Burr Adam R. Burr Vincent T. Ma Vincent T. Ma Vincent T. Ma Vincent T. Ma Review of recent advances in managing periocular skin malignancies Frontiers in Oncology periocular malignancy cutaneous squamous cell carcinoma basal cell carcinoma melanoma Merkel cell carcinoma sebaceous gland carcinoma |
| title | Review of recent advances in managing periocular skin malignancies |
| title_full | Review of recent advances in managing periocular skin malignancies |
| title_fullStr | Review of recent advances in managing periocular skin malignancies |
| title_full_unstemmed | Review of recent advances in managing periocular skin malignancies |
| title_short | Review of recent advances in managing periocular skin malignancies |
| title_sort | review of recent advances in managing periocular skin malignancies |
| topic | periocular malignancy cutaneous squamous cell carcinoma basal cell carcinoma melanoma Merkel cell carcinoma sebaceous gland carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1275930/full |
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