Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System
We propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post...
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MDPI AG
2018-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/18/11/3788 |
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| author | Yang Xu Lixuan Shi Tian Guan Suyi Zhong Xuesi Zhou Dongmei Li Cuixia Guo Yuxuan Yang Xiangnan Wang Zhangyan Li Yonghong He Luyuan Xie Zonghan Gan |
| author_facet | Yang Xu Lixuan Shi Tian Guan Suyi Zhong Xuesi Zhou Dongmei Li Cuixia Guo Yuxuan Yang Xiangnan Wang Zhangyan Li Yonghong He Luyuan Xie Zonghan Gan |
| author_sort | Yang Xu |
| collection | DOAJ |
| description | We propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post-selection polarization state. We obtained the sum and difference of the optical rotations produced by the sample and the standard by rotating the quarter wave plate in the system. Then, we estimate the ratio of chiral molecules to enantiomeric impurities using the ratio of the central wavelength shifts caused by the addition and subtraction states described above. In this paper, our system has an optical resolution of 1.88 × 10<sup>−5</sup>°. At the same time, we completed the detection of the ratio of the two substances in the mixture of L-proline and D-proline in different proportions, which proved that our system can quickly detect the content of enantiomeric impurities in chiral molecules. |
| first_indexed | 2024-04-11T21:59:07Z |
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| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T21:59:07Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-05611e9eb4e74cc69b90b649a0f2bf302022-12-22T04:00:59ZengMDPI AGSensors1424-82202018-11-011811378810.3390/s18113788s18113788Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement SystemYang Xu0Lixuan Shi1Tian Guan2Suyi Zhong3Xuesi Zhou4Dongmei Li5Cuixia Guo6Yuxuan Yang7Xiangnan Wang8Zhangyan Li9Yonghong He10Luyuan Xie11Zonghan Gan12Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaCenter for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaDivision of biomedical engineering, University of Glasgow, 89 Dumbarton Rd, Glasgow G12 8QQ, UKWe propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post-selection polarization state. We obtained the sum and difference of the optical rotations produced by the sample and the standard by rotating the quarter wave plate in the system. Then, we estimate the ratio of chiral molecules to enantiomeric impurities using the ratio of the central wavelength shifts caused by the addition and subtraction states described above. In this paper, our system has an optical resolution of 1.88 × 10<sup>−5</sup>°. At the same time, we completed the detection of the ratio of the two substances in the mixture of L-proline and D-proline in different proportions, which proved that our system can quickly detect the content of enantiomeric impurities in chiral molecules.https://www.mdpi.com/1424-8220/18/11/3788weak measurementself-referencecommon light path systemenantiomeric impurity content detection |
| spellingShingle | Yang Xu Lixuan Shi Tian Guan Suyi Zhong Xuesi Zhou Dongmei Li Cuixia Guo Yuxuan Yang Xiangnan Wang Zhangyan Li Yonghong He Luyuan Xie Zonghan Gan Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System Sensors weak measurement self-reference common light path system enantiomeric impurity content detection |
| title | Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System |
| title_full | Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System |
| title_fullStr | Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System |
| title_full_unstemmed | Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System |
| title_short | Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System |
| title_sort | rapid separation of enantiomeric impurities in chiral molecules by a self referential weak measurement system |
| topic | weak measurement self-reference common light path system enantiomeric impurity content detection |
| url | https://www.mdpi.com/1424-8220/18/11/3788 |
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