Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals
Based on the analysis of the results obtained by quantum chemical modeling of interaction between reduced glutathione (GSH) and melatonin (MLT) molecules with oxygen radicals (•OH and • OOˉ) it was found that this interaction occured following the acid-base mechanism, where MLT and GSH acted as a ba...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2017-12-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/2017/12/antioxidant-activity-of-melatonin-and-glutathione-interacting-with-hydroxyl-and-superoxide-anion-radicals.html |
| _version_ | 1797641727630114816 |
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| author | T. Y. Kuznetsova N. V. Solovyova V. V. Solovyov V. O. Kostenko |
| author_facet | T. Y. Kuznetsova N. V. Solovyova V. V. Solovyov V. O. Kostenko |
| author_sort | T. Y. Kuznetsova |
| collection | DOAJ |
| description | Based on the analysis of the results obtained by quantum chemical modeling of interaction between reduced glutathione (GSH) and melatonin (MLT) molecules with oxygen radicals (•OH and • OOˉ) it was found that this interaction occured following the acid-base mechanism, where MLT and GSH acted as a base in respect of •OH, and as acid in respect of •OOˉ. We have carried out the correlation of the results of quantum chemical calculations (density redistribution, energetic characteristics) under the interaction of MLT and GSH molecules with •OH and •OOˉ in changing macroscopic properties of the process of electroreduction of free oxygen radicals in the presence of antioxidants (potential and maximal current wave reduction waves). This was a direct experimental macroscale evidence of the results of theoretical modeling at the nanoscale level that pointed to a marked antioxidant activity of glutathione compared with melatonin. |
| first_indexed | 2024-03-11T13:49:49Z |
| format | Article |
| id | doaj.art-0562d1442032486f9b2fb3dcfed941a6 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:49:49Z |
| publishDate | 2017-12-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-0562d1442032486f9b2fb3dcfed941a62023-11-02T09:08:35ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032017-12-01896223010.15407/ubj89.06.022Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicalsT. Y. Kuznetsova0 N. V. Solovyova1V. V. Solovyov2V. O. Kostenko3Yu.Kondratyuk Poltava National Technical University, Ukraine;Ukrainian Medical Stomatological Academy, Poltava;Yu.Kondratyuk Poltava National Technical University, Ukraine;Ukrainian Medical Stomatological Academy, Poltava;Based on the analysis of the results obtained by quantum chemical modeling of interaction between reduced glutathione (GSH) and melatonin (MLT) molecules with oxygen radicals (•OH and • OOˉ) it was found that this interaction occured following the acid-base mechanism, where MLT and GSH acted as a base in respect of •OH, and as acid in respect of •OOˉ. We have carried out the correlation of the results of quantum chemical calculations (density redistribution, energetic characteristics) under the interaction of MLT and GSH molecules with •OH and •OOˉ in changing macroscopic properties of the process of electroreduction of free oxygen radicals in the presence of antioxidants (potential and maximal current wave reduction waves). This was a direct experimental macroscale evidence of the results of theoretical modeling at the nanoscale level that pointed to a marked antioxidant activity of glutathione compared with melatonin.http://ukrbiochemjournal.org/2017/12/antioxidant-activity-of-melatonin-and-glutathione-interacting-with-hydroxyl-and-superoxide-anion-radicals.htmlantioxidantsglutathionehydroxyl radicalmelatoninsuperoxide-anion-radical |
| spellingShingle | T. Y. Kuznetsova N. V. Solovyova V. V. Solovyov V. O. Kostenko Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals The Ukrainian Biochemical Journal antioxidants glutathione hydroxyl radical melatonin superoxide-anion-radical |
| title | Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals |
| title_full | Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals |
| title_fullStr | Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals |
| title_full_unstemmed | Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals |
| title_short | Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals |
| title_sort | antioxidant activity of melatonin and glutathione interacting with hydroxyl and superoxide anion radicals |
| topic | antioxidants glutathione hydroxyl radical melatonin superoxide-anion-radical |
| url | http://ukrbiochemjournal.org/2017/12/antioxidant-activity-of-melatonin-and-glutathione-interacting-with-hydroxyl-and-superoxide-anion-radicals.html |
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