Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditio...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022017844 |
| _version_ | 1818028633410764800 |
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| author | Hossein Biganeh Mahdi Kabiri Yahya Zeynalpourfattahi Rose Meire Costa Brancalhão Mehrdad Karimi Mohammad Reza Shams Ardekani Roja Rahimi |
| author_facet | Hossein Biganeh Mahdi Kabiri Yahya Zeynalpourfattahi Rose Meire Costa Brancalhão Mehrdad Karimi Mohammad Reza Shams Ardekani Roja Rahimi |
| author_sort | Hossein Biganeh |
| collection | DOAJ |
| description | Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range. |
| first_indexed | 2024-12-10T05:06:54Z |
| format | Article |
| id | doaj.art-056456ca02944cb19abf62fad39296f9 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-10T05:06:54Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-056456ca02944cb19abf62fad39296f92022-12-22T02:01:13ZengElsevierHeliyon2405-84402022-09-0189e10496Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activitiesHossein Biganeh0Mahdi Kabiri1Yahya Zeynalpourfattahi2Rose Meire Costa Brancalhão3Mehrdad Karimi4Mohammad Reza Shams Ardekani5Roja Rahimi6Department of Pharmacognosy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, IranDepartment of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, IranCenter of Biological Sciences and Health, State University of Western Paraná, Rua Universitária, 2069, 85819-110, Cascavel, PR, BrazilDepartment of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranPhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author.Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range.http://www.sciencedirect.com/science/article/pii/S2405844022017844Silk cocoonAminoacidProteinFibroinSericinHeart |
| spellingShingle | Hossein Biganeh Mahdi Kabiri Yahya Zeynalpourfattahi Rose Meire Costa Brancalhão Mehrdad Karimi Mohammad Reza Shams Ardekani Roja Rahimi Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities Heliyon Silk cocoon Aminoacid Protein Fibroin Sericin Heart |
| title | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
| title_full | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
| title_fullStr | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
| title_full_unstemmed | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
| title_short | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
| title_sort | bombyx mori cocoon as a promising pharmacological agent a review of ethnopharmacology chemistry and biological activities |
| topic | Silk cocoon Aminoacid Protein Fibroin Sericin Heart |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022017844 |
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