Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis
Background: Psoriasis goes beyond skin, intertwining with body systems, notably connecting to nonalcoholic fatty liver disease (NAFLD). This study aims to explore the predictive potential: liver function tests and IL-6 as early markers for non-alcoholic fatty liver disease in psoriasis patients. ...
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| Format: | Article |
| Language: | English |
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Journal of Ideas in Health
2023-12-01
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| Series: | Journal of Ideas in Health |
| Subjects: | |
| Online Access: | http://www.jidhealth.com/index.php/jidhealth/article/view/321 |
| _version_ | 1827380710729580544 |
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| author | Tadamun Adbullah Alyaa Ali Saad Ahmed Ali Jadoo Ismail Latif Khudhair Khalaf Alkayally Alkayally Raghad Salman |
| author_facet | Tadamun Adbullah Alyaa Ali Saad Ahmed Ali Jadoo Ismail Latif Khudhair Khalaf Alkayally Alkayally Raghad Salman |
| author_sort | Tadamun Adbullah |
| collection | DOAJ |
| description |
Background: Psoriasis goes beyond skin, intertwining with body systems, notably connecting to nonalcoholic fatty liver disease (NAFLD). This study aims to explore the predictive potential: liver function tests and IL-6 as early markers for non-alcoholic fatty liver disease in psoriasis patients.
Methods: From March to November 2023, a case-control study was performed at the dermatological outpatient clinic of Baquba Teaching Hospital, Iraq. Individuals with confirmed psoriasis and those without underwent comprehensive clinical history and overall health examinations. The diagnosis of non-alcoholic fatty liver disease (NAFLD) was established using the Fatty Liver Index (FLI).
Results: Among the 290 participants in this study, 103 with confirmed psoriasis displayed a Fatty Liver Index (FLI) score >60, indicative of non-alcoholic fatty liver disease (NAFLD). The control group, comprising 101 individuals without psoriasis or NAFLD, provided a baseline for comparison. The mean ages were 32.5 ± 16.2 and 31.5 ± 14.3 years for the case and control groups, respectively. Notably, the case group exhibited significantly higher mean ± SD levels of ALT and AST (61 ± 29 vs. 33 ± 17 U/L, p < 0.0001) and (55 ± 27 vs. 25 ± 15 U/L, p < 0.0001), respectively. Moreover, FLI criteria were markedly elevated in the case group (p = 0.0007, p = 0.0005, p < 0.0001, and p < 0.0001, respectively), and IL-6 levels were significantly higher (p = 0.0003).
Conclusion: The results proposed that liver function tests and IL-6 could act as early predictors for the detection of non-alcoholic fatty liver disease among individuals grappling with psoriasis.
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| first_indexed | 2024-03-08T13:37:55Z |
| format | Article |
| id | doaj.art-0566c5b21334407497e4d00ad11155f9 |
| institution | Directory Open Access Journal |
| issn | 2645-9248 |
| language | English |
| last_indexed | 2024-03-08T13:37:55Z |
| publishDate | 2023-12-01 |
| publisher | Journal of Ideas in Health |
| record_format | Article |
| series | Journal of Ideas in Health |
| spelling | doaj.art-0566c5b21334407497e4d00ad11155f92024-01-16T13:41:20ZengJournal of Ideas in HealthJournal of Ideas in Health2645-92482023-12-016410.47108/jidhealth.Vol6.Iss4.321Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis Tadamun Adbullah0Alyaa Ali1Saad Ahmed Ali Jadoo2Ismail Latif3Khudhair Khalaf Alkayally Alkayally4Raghad Salman5Department of Microbiology, College of Medicine, University of Diyala, Diyala, IraqDepartment of Microbiology, College of Medicine University of Diyala, Diyala, IraqDepartment of Family and Community Medicine, College of Medicine, University of Diyala, Diyala, IraqMedical Immunology, College of Medicine, University of Diyala, Diyala, IraqDepartment of Medicine, College of Medicine, University of Diyala, Diyala, Iraq.Department of Microbiology, College of Medicine University of Diyala, Diyala, Iraq Background: Psoriasis goes beyond skin, intertwining with body systems, notably connecting to nonalcoholic fatty liver disease (NAFLD). This study aims to explore the predictive potential: liver function tests and IL-6 as early markers for non-alcoholic fatty liver disease in psoriasis patients. Methods: From March to November 2023, a case-control study was performed at the dermatological outpatient clinic of Baquba Teaching Hospital, Iraq. Individuals with confirmed psoriasis and those without underwent comprehensive clinical history and overall health examinations. The diagnosis of non-alcoholic fatty liver disease (NAFLD) was established using the Fatty Liver Index (FLI). Results: Among the 290 participants in this study, 103 with confirmed psoriasis displayed a Fatty Liver Index (FLI) score >60, indicative of non-alcoholic fatty liver disease (NAFLD). The control group, comprising 101 individuals without psoriasis or NAFLD, provided a baseline for comparison. The mean ages were 32.5 ± 16.2 and 31.5 ± 14.3 years for the case and control groups, respectively. Notably, the case group exhibited significantly higher mean ± SD levels of ALT and AST (61 ± 29 vs. 33 ± 17 U/L, p < 0.0001) and (55 ± 27 vs. 25 ± 15 U/L, p < 0.0001), respectively. Moreover, FLI criteria were markedly elevated in the case group (p = 0.0007, p = 0.0005, p < 0.0001, and p < 0.0001, respectively), and IL-6 levels were significantly higher (p = 0.0003). Conclusion: The results proposed that liver function tests and IL-6 could act as early predictors for the detection of non-alcoholic fatty liver disease among individuals grappling with psoriasis. http://www.jidhealth.com/index.php/jidhealth/article/view/321P. aeruginosa, ERIC-PCR, ESBLs, fingerprint analysis |
| spellingShingle | Tadamun Adbullah Alyaa Ali Saad Ahmed Ali Jadoo Ismail Latif Khudhair Khalaf Alkayally Alkayally Raghad Salman Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis Journal of Ideas in Health P. aeruginosa, ERIC-PCR, ESBLs, fingerprint analysis |
| title | Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis |
| title_full | Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis |
| title_fullStr | Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis |
| title_full_unstemmed | Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis |
| title_short | Bridging the diagnostic gap: liver function tests and IL-6 as potential early predictors of non-alcoholic fatty liver disease in psoriasis |
| title_sort | bridging the diagnostic gap liver function tests and il 6 as potential early predictors of non alcoholic fatty liver disease in psoriasis |
| topic | P. aeruginosa, ERIC-PCR, ESBLs, fingerprint analysis |
| url | http://www.jidhealth.com/index.php/jidhealth/article/view/321 |
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