Bilateral exudative retinal detachments after subretinal gene therapy with voretigene neparvovec-rzyl for RPE65 Leber Congenital Amaurosis

Bilateral exudative retinal detachments after subretinal gene therapy with voretigene neparvovec-rzyl for RPE65 Leber Congenital Amaurosis

Purpose: To report panuveitis with exudative retinal detachments in a healthy 27-year-old woman with biallelic mutations in the RPE65 gene, who underwent bilateral sequential gene therapy with subretinal administration of voretigene neparvovec-rzyl. Observations: Visual acuity improved for 30 days a...

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Bibliographic Details
Main Authors:	Alcina K. Lidder, Stephanie Choi, Yasha S. Modi, Scott E. Brodie, Janet L. Davis, Ninel Z. Gregori, Byron L. Lam
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	American Journal of Ophthalmology Case Reports
Subjects:	Subretinal gene therapy Leber congenital amaurosis Vogt-koyanagi-harada disease Sympathetic ophthalmia RPE65-Associated inherited retinal disease Panuveitis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2451993623000877

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