Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation

Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation

Dysregulation of glutamate homeostasis is a well-established core feature of neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate transporter 1 (GLT-1). The discovery of a beta-lactam antibiotic, ceftriaxone (CEF), as a safe compound with unique ability to upre...

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Bibliographic Details
Main Authors: Osama A. Abulseoud, Fawaz Alasmari, Abdelaziz M. Hussein, Youssef Sari
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Neuroscience
Subjects:
ceftriaxone
glutamate
GLT-1
neurological disorder
psychiatric disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.841036/full

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