Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease
Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.01063/full |
| _version_ | 1811206134935060480 |
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| author | Gabrielle Lapping-Carr Joanna Gemel Yifan Mao Eric C. Beyer |
| author_facet | Gabrielle Lapping-Carr Joanna Gemel Yifan Mao Eric C. Beyer |
| author_sort | Gabrielle Lapping-Carr |
| collection | DOAJ |
| description | Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases, the plasma of sickle cell patients contains EVs of different sizes and cellular sources. The medium-sized vesicles (microparticles) primarily derive from mature red blood cells and platelets; some of these EVs have procoagulant properties, while others stimulate inflammation or endothelial adhesiveness. Most of the small EVs (including exosomes) derive from erythrocytes and erythrocyte precursors, but some also originate from platelets, white blood cells, and endothelial cells. These small EVs may alter the behavior of target cells by delivering cargo including proteins and nucleic acids. Studies in model systems implicate small EVs in promoting vaso-occlusion and disruption of endothelial integrity. Thus, both medium and small EVs may contribute to the increased endothelial damage in sickle cell disease. Development of a detailed understanding of the composition and roles of circulating EVs represents a promising approach toward novel predictive diagnostics and therapeutic approaches in sickle cell disease. |
| first_indexed | 2024-04-12T03:42:45Z |
| format | Article |
| id | doaj.art-0568afc5e87745379e073aaad6e75d26 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T03:42:45Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-0568afc5e87745379e073aaad6e75d262022-12-22T03:49:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.01063549593Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell DiseaseGabrielle Lapping-CarrJoanna GemelYifan MaoEric C. BeyerEndothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases, the plasma of sickle cell patients contains EVs of different sizes and cellular sources. The medium-sized vesicles (microparticles) primarily derive from mature red blood cells and platelets; some of these EVs have procoagulant properties, while others stimulate inflammation or endothelial adhesiveness. Most of the small EVs (including exosomes) derive from erythrocytes and erythrocyte precursors, but some also originate from platelets, white blood cells, and endothelial cells. These small EVs may alter the behavior of target cells by delivering cargo including proteins and nucleic acids. Studies in model systems implicate small EVs in promoting vaso-occlusion and disruption of endothelial integrity. Thus, both medium and small EVs may contribute to the increased endothelial damage in sickle cell disease. Development of a detailed understanding of the composition and roles of circulating EVs represents a promising approach toward novel predictive diagnostics and therapeutic approaches in sickle cell disease.https://www.frontiersin.org/article/10.3389/fphys.2020.01063/fullsickle cell diseaseextracellular vesicleexosomesmicrovesicleendothelial damage |
| spellingShingle | Gabrielle Lapping-Carr Joanna Gemel Yifan Mao Eric C. Beyer Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease Frontiers in Physiology sickle cell disease extracellular vesicle exosomes microvesicle endothelial damage |
| title | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
| title_full | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
| title_fullStr | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
| title_full_unstemmed | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
| title_short | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
| title_sort | circulating extracellular vesicles and endothelial damage in sickle cell disease |
| topic | sickle cell disease extracellular vesicle exosomes microvesicle endothelial damage |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.01063/full |
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