A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective disturbance on pain in older adults: A protocol for the sleep and Healthy Aging Research for pain (SHARE-P) study

A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective disturbance on pain in older adults: A protocol for the sleep and Healthy Aging Research for pain (SHARE-P) study

Chronic pain is prevalent in older adults. Treatment, especially with opioids, is often ineffective and poses considerable negative consequences in this population. To improve treatment, it is important to understand why older adults are at a heightened risk for developing chronic pain. Insomnia is...

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Bibliographic Details
Main Authors: Caitlin M. DuPont, Richard Olmstead, Matthew J. Reid, Katrina R. Hamilton, Claudia M. Campbell, Patrick H. Finan, Nina Sadeghi, Daisy Castillo, Michael R. Irwin, Michael T. Smith
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Endotoxin
Inflammation
Positive affect
Negative affect
Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S266635462300056X

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