Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation
Purpose This study evaluated the role of donor kidney ultrasonography (US) for predicting functional kidney volume and identifying ideal kidney grafts in deceased donor kidney transplantation. Methods In total, 272 patients who underwent deceased donor kidney transplantation from 2000 to 2020 at Sam...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2023-04-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-22132.pdf |
| _version_ | 1797853425009950720 |
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| author | Sang Oh Yun Kyo Won Lee Jae Berm Park Min Jung Kim Sung Yoon Park Boram Park |
| author_facet | Sang Oh Yun Kyo Won Lee Jae Berm Park Min Jung Kim Sung Yoon Park Boram Park |
| author_sort | Sang Oh Yun |
| collection | DOAJ |
| description | Purpose This study evaluated the role of donor kidney ultrasonography (US) for predicting functional kidney volume and identifying ideal kidney grafts in deceased donor kidney transplantation. Methods In total, 272 patients who underwent deceased donor kidney transplantation from 2000 to 2020 at Samsung Medical Center were enrolled. Donor kidney information (i.e., right or left) was provided to the radiologist who performed US image re-analysis. To binarize each kidney’s ultrasound parameters, an optimal cutoff value for estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m2 within 1 year after kidney transplantation was selected using the receiver operating characteristic curve with a specificity >60%. Cox regression analysis was performed for an eGFR less than 30 mL/min/1.73 m2 within 1 year after kidney transplantation and graft failure within 2 years after kidney transplantation. Results The product of renal length and cortical thickness was a statistically significant predictor of graft function. The odds ratios of an eGFR less than 30 mL/min/1.73 m2 within a year after kidney transplantation and the hazard ratio of graft failure within 2 years after kidney transplantation were 5.91 (P=0.003) and 5.76 (P=0.022), respectively. Conclusion Preoperative US of the donor kidney can be used to evaluate donor kidney function and can predict short-term graft survival. An imaging modality such as US should be included in the donor selection criteria as an additional recommendation. However, the purpose of this study was not to narrow the expanded criteria but to avoid catastrophic consequences by identifying ideal donor kidneys using preoperative US. |
| first_indexed | 2024-04-09T19:50:27Z |
| format | Article |
| id | doaj.art-056b4e5cc76d4eb982c028d7f4c6462e |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-04-09T19:50:27Z |
| publishDate | 2023-04-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-056b4e5cc76d4eb982c028d7f4c6462e2023-04-03T06:45:11ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-04-0142223824810.14366/usg.221321646Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantationSang Oh Yun0Kyo Won Lee1Jae Berm Park2Min Jung Kim3Sung Yoon Park4Boram Park5 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Surgery, Seoul Medical Center, Seoul, Korea Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, KoreaPurpose This study evaluated the role of donor kidney ultrasonography (US) for predicting functional kidney volume and identifying ideal kidney grafts in deceased donor kidney transplantation. Methods In total, 272 patients who underwent deceased donor kidney transplantation from 2000 to 2020 at Samsung Medical Center were enrolled. Donor kidney information (i.e., right or left) was provided to the radiologist who performed US image re-analysis. To binarize each kidney’s ultrasound parameters, an optimal cutoff value for estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m2 within 1 year after kidney transplantation was selected using the receiver operating characteristic curve with a specificity >60%. Cox regression analysis was performed for an eGFR less than 30 mL/min/1.73 m2 within 1 year after kidney transplantation and graft failure within 2 years after kidney transplantation. Results The product of renal length and cortical thickness was a statistically significant predictor of graft function. The odds ratios of an eGFR less than 30 mL/min/1.73 m2 within a year after kidney transplantation and the hazard ratio of graft failure within 2 years after kidney transplantation were 5.91 (P=0.003) and 5.76 (P=0.022), respectively. Conclusion Preoperative US of the donor kidney can be used to evaluate donor kidney function and can predict short-term graft survival. An imaging modality such as US should be included in the donor selection criteria as an additional recommendation. However, the purpose of this study was not to narrow the expanded criteria but to avoid catastrophic consequences by identifying ideal donor kidneys using preoperative US.http://www.e-ultrasonography.org/upload/usg-22132.pdfultrasounddeceased donor kidney transplantationexpanded criteria donorgraft survival |
| spellingShingle | Sang Oh Yun Kyo Won Lee Jae Berm Park Min Jung Kim Sung Yoon Park Boram Park Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation Ultrasonography ultrasound deceased donor kidney transplantation expanded criteria donor graft survival |
| title | Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| title_full | Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| title_fullStr | Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| title_full_unstemmed | Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| title_short | Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| title_sort | impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation |
| topic | ultrasound deceased donor kidney transplantation expanded criteria donor graft survival |
| url | http://www.e-ultrasonography.org/upload/usg-22132.pdf |
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