Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges

Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges

Abstract Background To introduce and compare multiple biological effectiveness guided (BG) proton plan optimization strategies minimizing variable relative biological effectiveness (RBE) induced dose burden in organs at risk (OAR) while maintaining plan quality with a constant RBE. Methods Dose-opti...

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Bibliographic Details
Main Authors: Christian Hahn, Lena Heuchel, Jakob Ödén, Erik Traneus, Jörg Wulff, Sandija Plaude, Beate Timmermann, Christian Bäumer, Armin Lühr
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Radiation Oncology
Subjects:
Proton therapy
Treatment plan optimization
Linear energy transfer (LET)
Relative biological effectiveness (RBE)
Track ends
Dirty dose
Online Access:https://doi.org/10.1186/s13014-022-02143-x

Internet

https://doi.org/10.1186/s13014-022-02143-x

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