The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience
Introduction: Neuroendocrine differentiation in colorectal carcinomas, detected using immunohistochemistry and ultrastructural techniques, has been studied as a prognostic marker for invention of targeted therapy. There are a few studies done on this aspect which have shown conflicting results...
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JCDR Research and Publications Private Limited
2015-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6854/12800_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Pooja Kundapur Suresh Kausalya Kumari Sahu Radha Ramachandra Pai Hanaganahalli Basaviah Sridevi Kirthinath Ballal Binit Khandelia Jessica Minal Rajendra Annappa |
| author_facet | Pooja Kundapur Suresh Kausalya Kumari Sahu Radha Ramachandra Pai Hanaganahalli Basaviah Sridevi Kirthinath Ballal Binit Khandelia Jessica Minal Rajendra Annappa |
| author_sort | Pooja Kundapur Suresh |
| collection | DOAJ |
| description | Introduction: Neuroendocrine differentiation in colorectal
carcinomas, detected using immunohistochemistry and
ultrastructural techniques, has been studied as a prognostic
marker for invention of targeted therapy. There are a few studies
done on this aspect which have shown conflicting results
ranging from poor prognosis to no prognostic significance.
Aim: The aim of the study was to determine the clinical
significance of neuroendocrine differentiation in colorectal
carcinomas using immunohistochemical stains such as
chromogranin A & synaptophysin in relation to its prognostic
significance.
Materials and Methods: A retrospective study was
conducted wherein all the colorectal carcinomas,
received in the Department of Pathology, over a period
of 3 years, were reviewed. Neuroendocrine markers were
done on 53 cases of moderately, poorly and undifferentiated
adenocarcinomas. Based on the degree of immunoreactivity
for these markers, tumours were divided into group 0, group
1, group 2, group 3 & group 4. Group 0 & 1 were categorized
as neuroendocrine differentiation absent & group 2, 3 & 4 as
present. Neuroendocrine differentiation was correlated with
age, sex, grade, stage, diagnosis & survival. Follow up data of
the cases was recorded.
Results: Neuroendocrine differentiation was present in 18 cases
(33.9%). The degree of immunoreactivity for neuroendocrine
markers in present study were; group 0- 58%, 1- 7.5%, 2- 9%,
3- 13% & 4- 11%. The mean age of patients was 54 years with a
slight male preponderance {M:F::1.6:1}. Most of the carcinomas
with neuroendocrine differentiation belonged to Grade II (61%) &
Stage II & III (83%). Neuroendocrine differentiation did not show
any significant association with age, sex, location, histological
type, grade, stage & survival.
Conclusion: The above results indicate that the presence of
neuroendocrine differentiation cannot be recommended as a
prognostic marker in colorectal carcinomas. |
| first_indexed | 2024-12-11T00:30:06Z |
| format | Article |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T00:30:06Z |
| publishDate | 2015-12-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-056d1dddec514908866dca11e9f8e6852022-12-22T01:27:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-12-01912EC01EC0410.7860/JCDR/2015/12800.6854The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our ExperiencePooja Kundapur Suresh0Kausalya Kumari Sahu1Radha Ramachandra Pai2Hanaganahalli Basaviah Sridevi3Kirthinath Ballal4Binit Khandelia5Jessica Minal6Rajendra Annappa7Assistant Professor, Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.Additional Professor, Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.Professor, Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.Assistant Professor, Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.Assistant Professor, Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, India.Senior, Resident, Department of Pathology, Deen Dayal Upadhyay Hospital, New Delhi, India.Assistant Professor, Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.Assistant Professor, Department of Orthopedics, Kasturba Medical College, Manipal University, Mangalore, India.Introduction: Neuroendocrine differentiation in colorectal carcinomas, detected using immunohistochemistry and ultrastructural techniques, has been studied as a prognostic marker for invention of targeted therapy. There are a few studies done on this aspect which have shown conflicting results ranging from poor prognosis to no prognostic significance. Aim: The aim of the study was to determine the clinical significance of neuroendocrine differentiation in colorectal carcinomas using immunohistochemical stains such as chromogranin A & synaptophysin in relation to its prognostic significance. Materials and Methods: A retrospective study was conducted wherein all the colorectal carcinomas, received in the Department of Pathology, over a period of 3 years, were reviewed. Neuroendocrine markers were done on 53 cases of moderately, poorly and undifferentiated adenocarcinomas. Based on the degree of immunoreactivity for these markers, tumours were divided into group 0, group 1, group 2, group 3 & group 4. Group 0 & 1 were categorized as neuroendocrine differentiation absent & group 2, 3 & 4 as present. Neuroendocrine differentiation was correlated with age, sex, grade, stage, diagnosis & survival. Follow up data of the cases was recorded. Results: Neuroendocrine differentiation was present in 18 cases (33.9%). The degree of immunoreactivity for neuroendocrine markers in present study were; group 0- 58%, 1- 7.5%, 2- 9%, 3- 13% & 4- 11%. The mean age of patients was 54 years with a slight male preponderance {M:F::1.6:1}. Most of the carcinomas with neuroendocrine differentiation belonged to Grade II (61%) & Stage II & III (83%). Neuroendocrine differentiation did not show any significant association with age, sex, location, histological type, grade, stage & survival. Conclusion: The above results indicate that the presence of neuroendocrine differentiation cannot be recommended as a prognostic marker in colorectal carcinomas.https://jcdr.net/articles/PDF/6854/12800_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdfcarcinoma of colonchromograninsynaptophysinprognostic marker |
| spellingShingle | Pooja Kundapur Suresh Kausalya Kumari Sahu Radha Ramachandra Pai Hanaganahalli Basaviah Sridevi Kirthinath Ballal Binit Khandelia Jessica Minal Rajendra Annappa The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience Journal of Clinical and Diagnostic Research carcinoma of colon chromogranin synaptophysin prognostic marker |
| title | The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience |
| title_full | The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience |
| title_fullStr | The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience |
| title_full_unstemmed | The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience |
| title_short | The Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience |
| title_sort | prognostic significance of neuroendocrine differentiation in colorectal carcinomas our experience |
| topic | carcinoma of colon chromogranin synaptophysin prognostic marker |
| url | https://jcdr.net/articles/PDF/6854/12800_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
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