Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/8/1511 |
| _version_ | 1797411397981700096 |
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| author | Ricardo Pardillo-Díaz Patricia Pérez-García Carmen Castro Pedro Nunez-Abades Livia Carrascal |
| author_facet | Ricardo Pardillo-Díaz Patricia Pérez-García Carmen Castro Pedro Nunez-Abades Livia Carrascal |
| author_sort | Ricardo Pardillo-Díaz |
| collection | DOAJ |
| description | Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting common neurodegenerative pathways. It is well known that oxidative stress and the production of reactive oxygen radicals plays a key role in neuronal cell damage. It has been proposed that this stress, among other mechanisms, could contribute to neuronal degeneration and might be one of the factors triggering the development of these pathologies. Another common feature in most neurodegenerative diseases is neuron hyperexcitability, an aberrant electrical activity. This review, focusing mainly on primary motor cortex pyramidal neurons, critically evaluates the idea that oxidative stress and inflammation may be involved in neurodegeneration via their capacity to increase membrane excitability. |
| first_indexed | 2024-03-09T04:45:33Z |
| format | Article |
| id | doaj.art-056e3ec983ee4c2ea50f2c908b22a77e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:45:33Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-056e3ec983ee4c2ea50f2c908b22a77e2023-12-03T13:15:45ZengMDPI AGAntioxidants2076-39212022-08-01118151110.3390/antiox11081511Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative DiseasesRicardo Pardillo-Díaz0Patricia Pérez-García1Carmen Castro2Pedro Nunez-Abades3Livia Carrascal4Biomedical Research and Innovation Institute of Cadiz (INIBICA), 11003 Cadiz, SpainBiomedical Research and Innovation Institute of Cadiz (INIBICA), 11003 Cadiz, SpainBiomedical Research and Innovation Institute of Cadiz (INIBICA), 11003 Cadiz, SpainArea of Physiology, School of Medicine, University of Cádiz, 11003 Cadiz, SpainArea of Physiology, School of Medicine, University of Cádiz, 11003 Cadiz, SpainNeurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting common neurodegenerative pathways. It is well known that oxidative stress and the production of reactive oxygen radicals plays a key role in neuronal cell damage. It has been proposed that this stress, among other mechanisms, could contribute to neuronal degeneration and might be one of the factors triggering the development of these pathologies. Another common feature in most neurodegenerative diseases is neuron hyperexcitability, an aberrant electrical activity. This review, focusing mainly on primary motor cortex pyramidal neurons, critically evaluates the idea that oxidative stress and inflammation may be involved in neurodegeneration via their capacity to increase membrane excitability.https://www.mdpi.com/2076-3921/11/8/1511oxidative stressneurodegenerative diseaseshyperexcitabilitymotor neuron |
| spellingShingle | Ricardo Pardillo-Díaz Patricia Pérez-García Carmen Castro Pedro Nunez-Abades Livia Carrascal Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases Antioxidants oxidative stress neurodegenerative diseases hyperexcitability motor neuron |
| title | Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases |
| title_full | Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases |
| title_fullStr | Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases |
| title_full_unstemmed | Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases |
| title_short | Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases |
| title_sort | oxidative stress as a potential mechanism underlying membrane hyperexcitability in neurodegenerative diseases |
| topic | oxidative stress neurodegenerative diseases hyperexcitability motor neuron |
| url | https://www.mdpi.com/2076-3921/11/8/1511 |
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