Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis
Background and Purpose: Accurate differentiation of pancreatic ductal adenocarcinoma (PDAC) from mass-forming chronic pancreatitis (MFCP) is clinically significant. The application of dual-layer spectral detector CT (DLCT) in pancreas has been explored. This study aimed to investigate the value of D...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2024-01-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/1707102092694-1527276758.pdf |
| _version_ | 1797300262946209792 |
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| author | LIU Wei, XIE Tiansong, CHEN Lei, ZHANG Zehua, ZHOU Zhengrong |
| author_facet | LIU Wei, XIE Tiansong, CHEN Lei, ZHANG Zehua, ZHOU Zhengrong |
| author_sort | LIU Wei, XIE Tiansong, CHEN Lei, ZHANG Zehua, ZHOU Zhengrong |
| collection | DOAJ |
| description | Background and Purpose: Accurate differentiation of pancreatic ductal adenocarcinoma (PDAC) from mass-forming chronic pancreatitis (MFCP) is clinically significant. The application of dual-layer spectral detector CT (DLCT) in pancreas has been explored. This study aimed to investigate the value of DLCT in distinguishing resectable PDAC from MFCP. Methods: We retrospectively collected data of 33 patients with resectable PDAC and 19 patients with MFCP admitted to Fudan University Shanghai Cancer Center from September 1, 2021 to May 31, 2023. Prior to surgery, patients underwent enhanced DLCT scans, including arterial phase (AP), parenchymal phase (PP) and venous phase (VP). DLCT quantitative parameters, including attenuation enhancement fraction (AEF), lesion-to-parenchyma ratio (LPR) and iodine enhancement fraction (IEF) were calculated. Difference analysis was conducted using independent sample t-test or chi-square test. Univariate and multivariate analyses were performed using binary logistic regression. Receiver operating characteristic (ROC) curves were used for performance evaluation. P<0.05 was considered statistically significant. Results: Statistically significant differences were observed between PDAC and MFCP in AEF_AP/PP, LPR40_VP, IEF_PP/VP, carbohydrate antigen 19-9 (CA19-9) and double-duct sign (all P<0.05). The spectral combined model composed of LPR40_VP and IEF_PP/VP exhibited the best discriminatory efficacy, surpassing CA19-9, double-duct sign and AEF_AP/PP (all P<0.05). The combined model demonstrated an area under curve (AUC) of 0.841, sensitivity of 90%, specificity of 73%, and accuracy of 79%. Conclusion: DLCT has certain potential in differentiating resectable PDAC from MFCP. Spectral quantitative parameters can complement CA19-9 and outcome shortcomings of conventional CT in distinguishing resectable PDAC from MFCP. |
| first_indexed | 2024-03-07T23:03:45Z |
| format | Article |
| id | doaj.art-056f3715dc7941548952682f097870ca |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-03-07T23:03:45Z |
| publishDate | 2024-01-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-056f3715dc7941548952682f097870ca2024-02-22T06:28:59ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392024-01-01341677310.19401/j.cnki.1007-3639.2024.01.003Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitisLIU Wei, XIE Tiansong, CHEN Lei, ZHANG Zehua, ZHOU Zhengrong01. Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;2. Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer Center, Shanghai 201100, ChinaBackground and Purpose: Accurate differentiation of pancreatic ductal adenocarcinoma (PDAC) from mass-forming chronic pancreatitis (MFCP) is clinically significant. The application of dual-layer spectral detector CT (DLCT) in pancreas has been explored. This study aimed to investigate the value of DLCT in distinguishing resectable PDAC from MFCP. Methods: We retrospectively collected data of 33 patients with resectable PDAC and 19 patients with MFCP admitted to Fudan University Shanghai Cancer Center from September 1, 2021 to May 31, 2023. Prior to surgery, patients underwent enhanced DLCT scans, including arterial phase (AP), parenchymal phase (PP) and venous phase (VP). DLCT quantitative parameters, including attenuation enhancement fraction (AEF), lesion-to-parenchyma ratio (LPR) and iodine enhancement fraction (IEF) were calculated. Difference analysis was conducted using independent sample t-test or chi-square test. Univariate and multivariate analyses were performed using binary logistic regression. Receiver operating characteristic (ROC) curves were used for performance evaluation. P<0.05 was considered statistically significant. Results: Statistically significant differences were observed between PDAC and MFCP in AEF_AP/PP, LPR40_VP, IEF_PP/VP, carbohydrate antigen 19-9 (CA19-9) and double-duct sign (all P<0.05). The spectral combined model composed of LPR40_VP and IEF_PP/VP exhibited the best discriminatory efficacy, surpassing CA19-9, double-duct sign and AEF_AP/PP (all P<0.05). The combined model demonstrated an area under curve (AUC) of 0.841, sensitivity of 90%, specificity of 73%, and accuracy of 79%. Conclusion: DLCT has certain potential in differentiating resectable PDAC from MFCP. Spectral quantitative parameters can complement CA19-9 and outcome shortcomings of conventional CT in distinguishing resectable PDAC from MFCP.http://www.china-oncology.com/fileup/1007-3639/PDF/1707102092694-1527276758.pdf|pancreatic ductal adenocarcinoma|mass-forming chronic pancreatitis|dual-layer spectral detector computed tomography|conventional computed tomography |
| spellingShingle | LIU Wei, XIE Tiansong, CHEN Lei, ZHANG Zehua, ZHOU Zhengrong Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis Zhongguo aizheng zazhi |pancreatic ductal adenocarcinoma|mass-forming chronic pancreatitis|dual-layer spectral detector computed tomography|conventional computed tomography |
| title | Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis |
| title_full | Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis |
| title_fullStr | Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis |
| title_full_unstemmed | Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis |
| title_short | Investigating the value of dual-layer spectral detector CT in distinguishing resectable pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis |
| title_sort | investigating the value of dual layer spectral detector ct in distinguishing resectable pancreatic ductal adenocarcinoma from mass forming chronic pancreatitis |
| topic | |pancreatic ductal adenocarcinoma|mass-forming chronic pancreatitis|dual-layer spectral detector computed tomography|conventional computed tomography |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/1707102092694-1527276758.pdf |
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