A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats
Anabolic Androgenic steroids (AAS) are abused and reports have been made on their deleterious effects on various organs. It is imperative to report the mechanism of inducing oxidative tissue damage even in the presence of an intracellular antioxidant system by the interaction between lipid peroxidat...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000239 |
| _version_ | 1797798847016075264 |
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| author | Adejoke Elizabeth Memudu Gambo A. Dongo |
| author_facet | Adejoke Elizabeth Memudu Gambo A. Dongo |
| author_sort | Adejoke Elizabeth Memudu |
| collection | DOAJ |
| description | Anabolic Androgenic steroids (AAS) are abused and reports have been made on their deleterious effects on various organs. It is imperative to report the mechanism of inducing oxidative tissue damage even in the presence of an intracellular antioxidant system by the interaction between lipid peroxidation and the antioxidant system in the kidney. Twenty (20) adult male Wistar rats used were grouped into: A- Control, BOlive oil vehicle, C- 120 mg/kg of AAS orally for three weeks, and D- 7 days withdrawal group following 120 mg/kg/ 21days of AAS intake. Serum was assayed for lipid peroxidation marker Malondialdehyde (MDA) and antioxidant enzyme –superoxide Dismutase (SOD). Sectioned of kidneys were stained to see the renal tissue, mucin granules, and basement membrane. AAS-induced oxidative tissue damage, in the presence of an endogenous antioxidant, is characterized by increased lipid peroxidation and decreased SOD level which resulted in the loss of renal tissue cells membrane integrity which is a characteristic of the pathophysiology of nephron toxicity induced by a toxic compound. However, this was progressively reversed by a period of discontinuation of AAS drug exposure. |
| first_indexed | 2024-03-13T04:10:53Z |
| format | Article |
| id | doaj.art-05706a7bf6ea44e9af9f5c05a055c8ab |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-13T04:10:53Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-05706a7bf6ea44e9af9f5c05a055c8ab2023-06-21T06:55:05ZengElsevierToxicology Reports2214-75002023-01-0110320326A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar RatsAdejoke Elizabeth Memudu0Gambo A. Dongo1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Edo State University Uzairue, Edo State Nigeria; Corresponding author.Department of Anatomy, Faculty of Basic Medical Sciences, Bingham University Karu Nasarawa State NigeriaAnabolic Androgenic steroids (AAS) are abused and reports have been made on their deleterious effects on various organs. It is imperative to report the mechanism of inducing oxidative tissue damage even in the presence of an intracellular antioxidant system by the interaction between lipid peroxidation and the antioxidant system in the kidney. Twenty (20) adult male Wistar rats used were grouped into: A- Control, BOlive oil vehicle, C- 120 mg/kg of AAS orally for three weeks, and D- 7 days withdrawal group following 120 mg/kg/ 21days of AAS intake. Serum was assayed for lipid peroxidation marker Malondialdehyde (MDA) and antioxidant enzyme –superoxide Dismutase (SOD). Sectioned of kidneys were stained to see the renal tissue, mucin granules, and basement membrane. AAS-induced oxidative tissue damage, in the presence of an endogenous antioxidant, is characterized by increased lipid peroxidation and decreased SOD level which resulted in the loss of renal tissue cells membrane integrity which is a characteristic of the pathophysiology of nephron toxicity induced by a toxic compound. However, this was progressively reversed by a period of discontinuation of AAS drug exposure.http://www.sciencedirect.com/science/article/pii/S2214750023000239Anabolic Androgenic SteroidAntioxidantNephrotoxicityLipid peroxidationOxidative stressBasement membrane |
| spellingShingle | Adejoke Elizabeth Memudu Gambo A. Dongo A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats Toxicology Reports Anabolic Androgenic Steroid Antioxidant Nephrotoxicity Lipid peroxidation Oxidative stress Basement membrane |
| title | A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats |
| title_full | A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats |
| title_fullStr | A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats |
| title_full_unstemmed | A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats |
| title_short | A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats |
| title_sort | study to demonstrate the potential of anabolic androgen steroid to activate oxidative tissue damage nephrotoxicity and decline endogenous antioxidant system in renal tissue of adult wistar rats |
| topic | Anabolic Androgenic Steroid Antioxidant Nephrotoxicity Lipid peroxidation Oxidative stress Basement membrane |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000239 |
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