IGF2BP3 promotes progression of gallbladder carcinoma by stabilizing KLK5 mRNA in N6-methyladenosine-dependent binding

IGF2BP3 promotes progression of gallbladder carcinoma by stabilizing KLK5 mRNA in N6-methyladenosine-dependent binding

BackgroundRecent studies have reported that IGF2BP3 is linked to the pathogenesis of various malignancies. Since IGF2BP3 is associated with poor outcomes of gallbladder carcinoma (GBC), we aimed to explore the association between its N6-methyladenosine (m6A) RNA methylation and GBC progression.Metho...

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Bibliographic Details
Main Authors: Junzhe Zhang, Kaini Yang, Junfeng Bu, Jiayan Yan, Xiaoqiang Hu, Ke Liu, Si Gao, Shuibin Tang, Lili Gao, Wei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
gallbladder carcinoma
IGF2BP3
KLK5
m6A reader
let-7g-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1035871/full

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