Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis
Hereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking abili...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.605282/full |
| _version_ | 1798037155963994112 |
|---|---|
| author | Maria do Carmo Vilas-Boas Maria do Carmo Vilas-Boas Ana Patrícia Rocha Márcio Neves Cardoso José Maria Fernandes Teresa Coelho João Paulo Silva Cunha |
| author_facet | Maria do Carmo Vilas-Boas Maria do Carmo Vilas-Boas Ana Patrícia Rocha Márcio Neves Cardoso José Maria Fernandes Teresa Coelho João Paulo Silva Cunha |
| author_sort | Maria do Carmo Vilas-Boas |
| collection | DOAJ |
| description | Hereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking ability from near onset. The detection of the latter is key for the disease's diagnosis. The aim of this work is to perform quantitative 3-D gait analysis in ATTRv V30M patients, at different disease stages, and explore the potential of the obtained gait information for supporting early diagnosis and/or stage distinction during follow-up. Sixty-six subjects (25 healthy controls, 14 asymptomatic ATTRv V30M carriers, and 27 symptomatic patients) were included in this case-control study. All subjects were asked to walk back and forth for 2 min, in front of a Kinect v2 camera prepared for body motion tracking. We then used our own software to extract gait-related parameters from the camera's 3-D body data. For each parameter, the main subject groups and symptomatic patient subgroups were statistically compared. Most of the explored gait parameters can potentially be used to distinguish between the considered group pairs. Despite of statistically significant differences being found, most of them were undetected to the naked eye. Our Kinect camera-based system is easy to use in clinical settings and provides quantitative gait information that can be useful for supporting clinical assessment during ATTRv V30M onset detection and follow-up, as well as developing more objective and fine-grained rating scales to further support the clinical decisions. |
| first_indexed | 2024-04-11T21:22:45Z |
| format | Article |
| id | doaj.art-05728230b54c491db22fb688f7f6ac56 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T21:22:45Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-05728230b54c491db22fb688f7f6ac562022-12-22T04:02:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-11-011110.3389/fneur.2020.605282605282Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin AmyloidosisMaria do Carmo Vilas-Boas0Maria do Carmo Vilas-Boas1Ana Patrícia Rocha2Márcio Neves Cardoso3José Maria Fernandes4Teresa Coelho5João Paulo Silva Cunha6INESC TEC, FEUP and LABIOMEP, University of Porto, Porto, PortugalUnidade Corino de Andrade and Neurophysiology Department, Centro Hospitalar Universitário do Porto, Porto, PortugalInstitute of Electronics and Informatics Engineering of Aveiro (IEETA), Department of Electronics, Telecommunications and Informatics, University of Aveiro, Aveiro, PortugalUnidade Corino de Andrade and Neurophysiology Department, Centro Hospitalar Universitário do Porto, Porto, PortugalInstitute of Electronics and Informatics Engineering of Aveiro (IEETA), Department of Electronics, Telecommunications and Informatics, University of Aveiro, Aveiro, PortugalUnidade Corino de Andrade and Neurophysiology Department, Centro Hospitalar Universitário do Porto, Porto, PortugalINESC TEC, FEUP and LABIOMEP, University of Porto, Porto, PortugalHereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking ability from near onset. The detection of the latter is key for the disease's diagnosis. The aim of this work is to perform quantitative 3-D gait analysis in ATTRv V30M patients, at different disease stages, and explore the potential of the obtained gait information for supporting early diagnosis and/or stage distinction during follow-up. Sixty-six subjects (25 healthy controls, 14 asymptomatic ATTRv V30M carriers, and 27 symptomatic patients) were included in this case-control study. All subjects were asked to walk back and forth for 2 min, in front of a Kinect v2 camera prepared for body motion tracking. We then used our own software to extract gait-related parameters from the camera's 3-D body data. For each parameter, the main subject groups and symptomatic patient subgroups were statistically compared. Most of the explored gait parameters can potentially be used to distinguish between the considered group pairs. Despite of statistically significant differences being found, most of them were undetected to the naked eye. Our Kinect camera-based system is easy to use in clinical settings and provides quantitative gait information that can be useful for supporting clinical assessment during ATTRv V30M onset detection and follow-up, as well as developing more objective and fine-grained rating scales to further support the clinical decisions.https://www.frontiersin.org/articles/10.3389/fneur.2020.605282/fullATTRv V30Mamyloidosispolyneuropathygaitquantitative assessmentambulatory |
| spellingShingle | Maria do Carmo Vilas-Boas Maria do Carmo Vilas-Boas Ana Patrícia Rocha Márcio Neves Cardoso José Maria Fernandes Teresa Coelho João Paulo Silva Cunha Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis Frontiers in Neurology ATTRv V30M amyloidosis polyneuropathy gait quantitative assessment ambulatory |
| title | Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis |
| title_full | Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis |
| title_fullStr | Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis |
| title_full_unstemmed | Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis |
| title_short | Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis |
| title_sort | clinical 3 d gait assessment of patients with polyneuropathy associated with hereditary transthyretin amyloidosis |
| topic | ATTRv V30M amyloidosis polyneuropathy gait quantitative assessment ambulatory |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.605282/full |
| work_keys_str_mv | AT mariadocarmovilasboas clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT mariadocarmovilasboas clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT anapatriciarocha clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT marcionevescardoso clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT josemariafernandes clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT teresacoelho clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis AT joaopaulosilvacunha clinical3dgaitassessmentofpatientswithpolyneuropathyassociatedwithhereditarytransthyretinamyloidosis |