Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component
This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/3/197 |
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| author | Mahbubur Rahman Stephanie Ahmad James Tarabokija Nathaniel Parker Ecevit Bilgili |
| author_facet | Mahbubur Rahman Stephanie Ahmad James Tarabokija Nathaniel Parker Ecevit Bilgili |
| author_sort | Mahbubur Rahman |
| collection | DOAJ |
| description | This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%−12.5% HPC/Sol with 0.125% SDS/without SDS were prepared in acetone−water and spray-dried. The solid-state characterization of the ASDs suggests that GF−Sol had better miscibility and stronger interactions than GF−HPC and formed XRPD-amorphous GF, whereas HPC-based ASDs, especially the ones with a lower HPC loading, had crystalline GF. The dissolution tests show that without SDS, ASDs provided limited GF supersaturation (max. 250%) due to poor wettability of Sol-based ASDs and extensive GF recrystallization in HPC-based ASDs (max. 50%). Sol-based ASDs with SDS exhibited a dramatic increase in supersaturation (max. 570%), especially at a higher Sol loading, whereas HPC-based ASDs with SDS did not. SDS did not interfere with Sol’s ability to inhibit GF recrystallization, as confirmed by the precipitation from the supersaturated state and PLM imaging. The favorable use of SDS in a ternary ASD was attributed to both the wettability enhancement and its inability to promote GF recrystallization when used as a minor component along with Sol. |
| first_indexed | 2024-04-13T00:48:20Z |
| format | Article |
| id | doaj.art-0573ab219b114f0a90f08aa4560946bc |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T00:48:20Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0573ab219b114f0a90f08aa4560946bc2022-12-22T03:09:56ZengMDPI AGPharmaceutics1999-49232020-02-0112319710.3390/pharmaceutics12030197pharmaceutics12030197Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor ComponentMahbubur Rahman0Stephanie Ahmad1James Tarabokija2Nathaniel Parker3Ecevit Bilgili4Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOtto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOtto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOtto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOtto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAThis study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%−12.5% HPC/Sol with 0.125% SDS/without SDS were prepared in acetone−water and spray-dried. The solid-state characterization of the ASDs suggests that GF−Sol had better miscibility and stronger interactions than GF−HPC and formed XRPD-amorphous GF, whereas HPC-based ASDs, especially the ones with a lower HPC loading, had crystalline GF. The dissolution tests show that without SDS, ASDs provided limited GF supersaturation (max. 250%) due to poor wettability of Sol-based ASDs and extensive GF recrystallization in HPC-based ASDs (max. 50%). Sol-based ASDs with SDS exhibited a dramatic increase in supersaturation (max. 570%), especially at a higher Sol loading, whereas HPC-based ASDs with SDS did not. SDS did not interfere with Sol’s ability to inhibit GF recrystallization, as confirmed by the precipitation from the supersaturated state and PLM imaging. The favorable use of SDS in a ternary ASD was attributed to both the wettability enhancement and its inability to promote GF recrystallization when used as a minor component along with Sol.https://www.mdpi.com/1999-4923/12/3/197amorphous solid dispersionsspray dryingwettabilitysupersaturationrecrystallizationdrug release |
| spellingShingle | Mahbubur Rahman Stephanie Ahmad James Tarabokija Nathaniel Parker Ecevit Bilgili Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component Pharmaceutics amorphous solid dispersions spray drying wettability supersaturation recrystallization drug release |
| title | Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component |
| title_full | Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component |
| title_fullStr | Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component |
| title_full_unstemmed | Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component |
| title_short | Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component |
| title_sort | spray dried amorphous solid dispersions of griseofulvin in hpc soluplus sds elucidating the multifaceted impact of sds as a minor component |
| topic | amorphous solid dispersions spray drying wettability supersaturation recrystallization drug release |
| url | https://www.mdpi.com/1999-4923/12/3/197 |
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