Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor
Background: Essential tremor (ET) is manifested as an isolated syndrome of bilateral upper limb action tremor. Parkinson's disease (PD) is the second most common neurodegenerative disease, with typical motor symptoms of bradykinesia, rigidity, and resting tremor. ET-PD describes the new-onset o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00874/full |
| _version_ | 1818531267754328064 |
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| author | Xi-Xi Wang Xi-Xi Wang Ya Feng Xuan Li Xiao-Ying Zhu Daniel Truong Daniel Truong William G. Ondo Yun-Cheng Wu |
| author_facet | Xi-Xi Wang Xi-Xi Wang Ya Feng Xuan Li Xiao-Ying Zhu Daniel Truong Daniel Truong William G. Ondo Yun-Cheng Wu |
| author_sort | Xi-Xi Wang |
| collection | DOAJ |
| description | Background: Essential tremor (ET) is manifested as an isolated syndrome of bilateral upper limb action tremor. Parkinson's disease (PD) is the second most common neurodegenerative disease, with typical motor symptoms of bradykinesia, rigidity, and resting tremor. ET-PD describes the new-onset of PD in ET patients. Recently, numerous studies on epidemiology, genetics, pathology, clinical features, and neuroimaging studies are challenging the idea that ET is an isolated disease, suggesting that patients with ET have the tendency to develop PD.Methods: In this review article, we collected recent findings that reveal prodromal markers of PD in patients with ET.Results: Substantia nigra hyperechogenicity serves as a prodromal marker for predicting the development of PD in patients with ET and provides a reference for therapeutic strategies. Additional potential markers include other neuroimaging, clinical features, heart rate, and genetics, whereas others lack sufficient evidence.Conclusion: In consideration of the limited research of PD in patients with ET, we are still far from revealing the prodromal markers. However, from the existing follow-up studies on ET patients, Substantia nigra hyperechogenicity may enable further exploration of the relationship between ET and PD and the search for pathogenesis-based therapies. |
| first_indexed | 2024-12-11T17:30:14Z |
| format | Article |
| id | doaj.art-057407d46aba4d108c85c398ecd5f6bc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T17:30:14Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-057407d46aba4d108c85c398ecd5f6bc2022-12-22T00:56:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-08-011110.3389/fneur.2020.00874532028Prodromal Markers of Parkinson's Disease in Patients With Essential TremorXi-Xi Wang0Xi-Xi Wang1Ya Feng2Xuan Li3Xiao-Ying Zhu4Daniel Truong5Daniel Truong6William G. Ondo7Yun-Cheng Wu8Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai General Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaOrange Coast Memorial Medical Center, The Truong Neurosciences Institute, Fountain Valley, CA, United StatesDepartment of Neurosciences and Psychiatry, University of California, Riverside, Riverside, CA, United StatesWeill Cornell Medical School, Methodist Neurological Institute, Houston, TX, United StatesDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackground: Essential tremor (ET) is manifested as an isolated syndrome of bilateral upper limb action tremor. Parkinson's disease (PD) is the second most common neurodegenerative disease, with typical motor symptoms of bradykinesia, rigidity, and resting tremor. ET-PD describes the new-onset of PD in ET patients. Recently, numerous studies on epidemiology, genetics, pathology, clinical features, and neuroimaging studies are challenging the idea that ET is an isolated disease, suggesting that patients with ET have the tendency to develop PD.Methods: In this review article, we collected recent findings that reveal prodromal markers of PD in patients with ET.Results: Substantia nigra hyperechogenicity serves as a prodromal marker for predicting the development of PD in patients with ET and provides a reference for therapeutic strategies. Additional potential markers include other neuroimaging, clinical features, heart rate, and genetics, whereas others lack sufficient evidence.Conclusion: In consideration of the limited research of PD in patients with ET, we are still far from revealing the prodromal markers. However, from the existing follow-up studies on ET patients, Substantia nigra hyperechogenicity may enable further exploration of the relationship between ET and PD and the search for pathogenesis-based therapies.https://www.frontiersin.org/article/10.3389/fneur.2020.00874/fullessential tremorParkinson's diseaseET-PDprodromal markerssubstantia nigra hyperechogenicity |
| spellingShingle | Xi-Xi Wang Xi-Xi Wang Ya Feng Xuan Li Xiao-Ying Zhu Daniel Truong Daniel Truong William G. Ondo Yun-Cheng Wu Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor Frontiers in Neurology essential tremor Parkinson's disease ET-PD prodromal markers substantia nigra hyperechogenicity |
| title | Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor |
| title_full | Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor |
| title_fullStr | Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor |
| title_full_unstemmed | Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor |
| title_short | Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor |
| title_sort | prodromal markers of parkinson s disease in patients with essential tremor |
| topic | essential tremor Parkinson's disease ET-PD prodromal markers substantia nigra hyperechogenicity |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00874/full |
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