Spinal cord injury drives chronic brain changes
Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1044;epage=1047;aulast=Jure |
| _version_ | 1828885862109151232 |
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| author | Ignacio Jure Florencia Labombarda |
| author_facet | Ignacio Jure Florencia Labombarda |
| author_sort | Ignacio Jure |
| collection | DOAJ |
| description | Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma. |
| first_indexed | 2024-12-13T11:34:19Z |
| format | Article |
| id | doaj.art-057424ce27a24608ba89828b778c5594 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-13T11:34:19Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-057424ce27a24608ba89828b778c55942022-12-21T23:47:50ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-011271044104710.4103/1673-5374.211177Spinal cord injury drives chronic brain changesIgnacio JureFlorencia LabombardaOnly a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1044;epage=1047;aulast=Jurespinal cord injury; brain neurodegeneration; neuroinflammation |
| spellingShingle | Ignacio Jure Florencia Labombarda Spinal cord injury drives chronic brain changes Neural Regeneration Research spinal cord injury; brain neurodegeneration; neuroinflammation |
| title | Spinal cord injury drives chronic brain changes |
| title_full | Spinal cord injury drives chronic brain changes |
| title_fullStr | Spinal cord injury drives chronic brain changes |
| title_full_unstemmed | Spinal cord injury drives chronic brain changes |
| title_short | Spinal cord injury drives chronic brain changes |
| title_sort | spinal cord injury drives chronic brain changes |
| topic | spinal cord injury; brain neurodegeneration; neuroinflammation |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1044;epage=1047;aulast=Jure |
| work_keys_str_mv | AT ignaciojure spinalcordinjurydriveschronicbrainchanges AT florencialabombarda spinalcordinjurydriveschronicbrainchanges |