Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease
Abstract Ischemic vascular disease is a major healthcare problem. The keys to treatment lie in vascular regeneration and restoration of perfusion. However, current treatments cannot satisfy the need for vascular regeneration to restore blood circulation. As biomedical research has evolved rapidly, a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-02-01
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| Series: | Journal of Biological Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13036-023-00330-2 |
| _version_ | 1797864467196805120 |
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| author | Xinyue Chen Wenlu Yu Jing Zhang Xiao Fan Xiao Liu Qi Liu Su Pan Richard A. F. Dixon Pengyang Li Peng Yu Ao Shi |
| author_facet | Xinyue Chen Wenlu Yu Jing Zhang Xiao Fan Xiao Liu Qi Liu Su Pan Richard A. F. Dixon Pengyang Li Peng Yu Ao Shi |
| author_sort | Xinyue Chen |
| collection | DOAJ |
| description | Abstract Ischemic vascular disease is a major healthcare problem. The keys to treatment lie in vascular regeneration and restoration of perfusion. However, current treatments cannot satisfy the need for vascular regeneration to restore blood circulation. As biomedical research has evolved rapidly, a variety of potential alternative therapeutics has been explored widely, such as growth factor-based therapy, cell-based therapy, and material-based therapy including nanomedicine and biomaterials. This review will comprehensively describe the main pathogenesis of vascular injury in ischemic vascular disease, the therapeutic function of the above three treatment strategies, the corresponding potential challenges, and future research directions. |
| first_indexed | 2024-04-09T22:52:24Z |
| format | Article |
| id | doaj.art-0575900d546a4a1caa1de63d09f65b77 |
| institution | Directory Open Access Journal |
| issn | 1754-1611 |
| language | English |
| last_indexed | 2024-04-09T22:52:24Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj.art-0575900d546a4a1caa1de63d09f65b772023-03-22T11:33:11ZengBMCJournal of Biological Engineering1754-16112023-02-0117112010.1186/s13036-023-00330-2Therapeutic angiogenesis and tissue revascularization in ischemic vascular diseaseXinyue Chen0Wenlu Yu1Jing Zhang2Xiao Fan3Xiao Liu4Qi Liu5Su Pan6Richard A. F. Dixon7Pengyang Li8Peng Yu9Ao Shi10The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang UniversitySchool of Ophthalmology and Optometry of Nanchang UniversityDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Sun Yat Sen UniversityWafic Said Molecular Cardiology Research Laboratory, The Texas Heart InstituteWafic Said Molecular Cardiology Research Laboratory, The Texas Heart InstituteWafic Said Molecular Cardiology Research Laboratory, The Texas Heart InstituteDivision of Cardiology, Pauley Heart Center, Virginia Commonwealth UniversityThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang UniversitySchool of Medicine, St. George University of LondonAbstract Ischemic vascular disease is a major healthcare problem. The keys to treatment lie in vascular regeneration and restoration of perfusion. However, current treatments cannot satisfy the need for vascular regeneration to restore blood circulation. As biomedical research has evolved rapidly, a variety of potential alternative therapeutics has been explored widely, such as growth factor-based therapy, cell-based therapy, and material-based therapy including nanomedicine and biomaterials. This review will comprehensively describe the main pathogenesis of vascular injury in ischemic vascular disease, the therapeutic function of the above three treatment strategies, the corresponding potential challenges, and future research directions.https://doi.org/10.1186/s13036-023-00330-2Ischemic vascular diseaseTherapeutic angiogenesisTissue revascularizationBiological therapy |
| spellingShingle | Xinyue Chen Wenlu Yu Jing Zhang Xiao Fan Xiao Liu Qi Liu Su Pan Richard A. F. Dixon Pengyang Li Peng Yu Ao Shi Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease Journal of Biological Engineering Ischemic vascular disease Therapeutic angiogenesis Tissue revascularization Biological therapy |
| title | Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| title_full | Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| title_fullStr | Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| title_full_unstemmed | Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| title_short | Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| title_sort | therapeutic angiogenesis and tissue revascularization in ischemic vascular disease |
| topic | Ischemic vascular disease Therapeutic angiogenesis Tissue revascularization Biological therapy |
| url | https://doi.org/10.1186/s13036-023-00330-2 |
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