Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC ActivationSummary

Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC ActivationSummary

Background & Aims: The O-class of the forkhead transcription factor FoxO1 is a crucial factor mediating insulin→PI3K→Akt signaling and governs diverse cellular processes. However, the role of hepatocyte FoxO1 in liver fibrosis has not been well-established. In his study, we investigated the...

Full description

Bibliographic Details
Main Authors: Quan Pan, Mingming Gao, DaMi Kim, Weiqi Ai, Wanbao Yang, Wen Jiang, Wesley Brashear, Yujiao Dai, Sha Li, Yuxiang Sun, Yajuan Qi, Shaodong Guo
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
FoxO1
Hepatic Stellate Cell
Inflammation
Liver Fibrosis
TGF-β1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X23001613

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X23001613

Similar Items