The role of spatial heterogeneity in the evolution of local and global infections of viruses.
Viruses have two modes spread in a host body, one is to release infectious particles from infected cells (global infection) and the other is to infect directly from an infected cell to an adjacent cell (local infection). Since the mode of spread affects the evolution of life history traits, such as...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC5800656?pdf=render |
| _version_ | 1818155322406076416 |
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| author | Koich Saeki Akira Sasaki |
| author_facet | Koich Saeki Akira Sasaki |
| author_sort | Koich Saeki |
| collection | DOAJ |
| description | Viruses have two modes spread in a host body, one is to release infectious particles from infected cells (global infection) and the other is to infect directly from an infected cell to an adjacent cell (local infection). Since the mode of spread affects the evolution of life history traits, such as virulence, it is important to reveal what level of global and local infection is selected. Previous studies of the evolution of global and local infection have paid little attention to its dependency on the measures of spatial configuration. Here we show the evolutionarily stable proportion of global and local infection, and how it depends on the distribution of target cells. Using an epidemic model on a regular lattice, we consider the infection dynamics by pair approximation and check the evolutionarily stable strategy. We also conduct the Monte-Carlo simulation to observe evolutionary dynamics. We show that a higher local infection is selected as target cells become clustered. Surprisingly, the selected strategy depends not only on the degree of clustering but also the abundance of target cells per se. |
| first_indexed | 2024-12-11T14:40:34Z |
| format | Article |
| id | doaj.art-05764bd9d19a4595a27be44535ace214 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-11T14:40:34Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-05764bd9d19a4595a27be44535ace2142022-12-22T01:01:56ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582018-01-01141e100595210.1371/journal.pcbi.1005952The role of spatial heterogeneity in the evolution of local and global infections of viruses.Koich SaekiAkira SasakiViruses have two modes spread in a host body, one is to release infectious particles from infected cells (global infection) and the other is to infect directly from an infected cell to an adjacent cell (local infection). Since the mode of spread affects the evolution of life history traits, such as virulence, it is important to reveal what level of global and local infection is selected. Previous studies of the evolution of global and local infection have paid little attention to its dependency on the measures of spatial configuration. Here we show the evolutionarily stable proportion of global and local infection, and how it depends on the distribution of target cells. Using an epidemic model on a regular lattice, we consider the infection dynamics by pair approximation and check the evolutionarily stable strategy. We also conduct the Monte-Carlo simulation to observe evolutionary dynamics. We show that a higher local infection is selected as target cells become clustered. Surprisingly, the selected strategy depends not only on the degree of clustering but also the abundance of target cells per se.http://europepmc.org/articles/PMC5800656?pdf=render |
| spellingShingle | Koich Saeki Akira Sasaki The role of spatial heterogeneity in the evolution of local and global infections of viruses. PLoS Computational Biology |
| title | The role of spatial heterogeneity in the evolution of local and global infections of viruses. |
| title_full | The role of spatial heterogeneity in the evolution of local and global infections of viruses. |
| title_fullStr | The role of spatial heterogeneity in the evolution of local and global infections of viruses. |
| title_full_unstemmed | The role of spatial heterogeneity in the evolution of local and global infections of viruses. |
| title_short | The role of spatial heterogeneity in the evolution of local and global infections of viruses. |
| title_sort | role of spatial heterogeneity in the evolution of local and global infections of viruses |
| url | http://europepmc.org/articles/PMC5800656?pdf=render |
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