Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer
Background/Aims: In this study, we aimed to evaluate the predictive value of localized stenosis of the main pancreatic duct (MPD) for early detection of pancreatic cancer. Methods: Among 689 patients who underwent endoscopic retrograde pancreatography from January 2008 to September 2018, 19 patients...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2019-11-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2019-018.pdf |
| _version_ | 1797668877555990528 |
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| author | Yoshihide Kanno Shinsuke Koshita Takahisa Ogawa Hiroaki Kusunose Kaori Masu Toshitaka Sakai Keisuke Yonamine Yujiro Kawakami Yuki Fujii Kazuaki Miyamoto Toji Murabayashi Fumisato Kozakai Jun Horaguchi Yutaka Noda Masaya Oikawa Takaho Okada Kei Ito |
| author_facet | Yoshihide Kanno Shinsuke Koshita Takahisa Ogawa Hiroaki Kusunose Kaori Masu Toshitaka Sakai Keisuke Yonamine Yujiro Kawakami Yuki Fujii Kazuaki Miyamoto Toji Murabayashi Fumisato Kozakai Jun Horaguchi Yutaka Noda Masaya Oikawa Takaho Okada Kei Ito |
| author_sort | Yoshihide Kanno |
| collection | DOAJ |
| description | Background/Aims: In this study, we aimed to evaluate the predictive value of localized stenosis of the main pancreatic duct (MPD) for early detection of pancreatic cancer. Methods: Among 689 patients who underwent endoscopic retrograde pancreatography from January 2008 to September 2018, 19 patients with MPD findings were enrolled. These patients showed findings for indicating suspicious pancreatic cancer at an early stage (FiCE); FiCE was defined as a single, localized stenosis in the MPD without a detectable mass (using any other imaging methods) and without other pancreatic diseases, such as definite chronic pancreatitis, intraductal papillary mucinous neoplasm, and autoimmune pancreatitis. Final diagnoses were established by examining resected specimens or through follow-up examinations after an interval of >5 years. Results: Among 19 patients with FiCE, 11 underwent surgical resection and 8 were evaluated after a >5-year observation period. The final diagnosis of the MPD stenosis was judged to be pancreatic cancer in 9 patients (47%), including 3 with intraepithelial cancer, and to be a non-neoplastic change in 10. The sensitivity, specificity, and accuracy of preoperative pancreatic juice cytology were 75%, 100%, and 88%, respectively. Conclusions: The predictive value of FiCE for pancreatic cancer prevalence was 47%. Histological confirmation with pancreatic juice cytology is necessary before surgical resection. |
| first_indexed | 2024-03-11T20:35:53Z |
| format | Article |
| id | doaj.art-0576b090543c46cdaabff334d71d977c |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-11T20:35:53Z |
| publishDate | 2019-11-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-0576b090543c46cdaabff334d71d977c2023-10-02T06:23:02ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432019-11-0152658859710.5946/ce.2019.0187297Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic CancerYoshihide Kanno0Shinsuke Koshita1Takahisa Ogawa2Hiroaki Kusunose3Kaori Masu4Toshitaka Sakai5Keisuke Yonamine6Yujiro Kawakami7Yuki Fujii8Kazuaki Miyamoto9Toji Murabayashi10Fumisato Kozakai11Jun Horaguchi12Yutaka Noda13Masaya Oikawa14Takaho Okada15Kei Ito16 Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterological Surgery, Sendai City Medical Center, Sendai, Japan Department of Gastroenterological Surgery, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, JapanBackground/Aims: In this study, we aimed to evaluate the predictive value of localized stenosis of the main pancreatic duct (MPD) for early detection of pancreatic cancer. Methods: Among 689 patients who underwent endoscopic retrograde pancreatography from January 2008 to September 2018, 19 patients with MPD findings were enrolled. These patients showed findings for indicating suspicious pancreatic cancer at an early stage (FiCE); FiCE was defined as a single, localized stenosis in the MPD without a detectable mass (using any other imaging methods) and without other pancreatic diseases, such as definite chronic pancreatitis, intraductal papillary mucinous neoplasm, and autoimmune pancreatitis. Final diagnoses were established by examining resected specimens or through follow-up examinations after an interval of >5 years. Results: Among 19 patients with FiCE, 11 underwent surgical resection and 8 were evaluated after a >5-year observation period. The final diagnosis of the MPD stenosis was judged to be pancreatic cancer in 9 patients (47%), including 3 with intraepithelial cancer, and to be a non-neoplastic change in 10. The sensitivity, specificity, and accuracy of preoperative pancreatic juice cytology were 75%, 100%, and 88%, respectively. Conclusions: The predictive value of FiCE for pancreatic cancer prevalence was 47%. Histological confirmation with pancreatic juice cytology is necessary before surgical resection.http://www.e-ce.org/upload/pdf/ce-2019-018.pdfearly pancreatic cancerendoscopic retrograde cholangiopancreatographyintraductal papillary mucinous neoplasmintraepithelial cancerpancreatic juice cytology |
| spellingShingle | Yoshihide Kanno Shinsuke Koshita Takahisa Ogawa Hiroaki Kusunose Kaori Masu Toshitaka Sakai Keisuke Yonamine Yujiro Kawakami Yuki Fujii Kazuaki Miyamoto Toji Murabayashi Fumisato Kozakai Jun Horaguchi Yutaka Noda Masaya Oikawa Takaho Okada Kei Ito Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer Clinical Endoscopy early pancreatic cancer endoscopic retrograde cholangiopancreatography intraductal papillary mucinous neoplasm intraepithelial cancer pancreatic juice cytology |
| title | Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer |
| title_full | Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer |
| title_fullStr | Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer |
| title_full_unstemmed | Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer |
| title_short | Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer |
| title_sort | predictive value of localized stenosis of the main pancreatic duct for early detection of pancreatic cancer |
| topic | early pancreatic cancer endoscopic retrograde cholangiopancreatography intraductal papillary mucinous neoplasm intraepithelial cancer pancreatic juice cytology |
| url | http://www.e-ce.org/upload/pdf/ce-2019-018.pdf |
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