Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy
Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/10/1330 |
| _version_ | 1797515117305266176 |
|---|---|
| author | Tammar Truzman Elizabeth Rochon Jed Meltzer Carol Leonard Tali Bitan |
| author_facet | Tammar Truzman Elizabeth Rochon Jed Meltzer Carol Leonard Tali Bitan |
| author_sort | Tammar Truzman |
| collection | DOAJ |
| description | Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI scans were administered to all participants with a 3.5-month interval. The fMRI scans included phonological and semantic tasks, each consisting of linguistic and perceptual matching conditions. Between the two fMRI scans, PWA underwent Phonological Components Analysis treatment. Changes in effective connectivity during the treatment were examined within right hemisphere (RH) architecture. The results illustrate that following the treatment, the averaged connectivity of PWA across all perceptual and linguistic conditions in both tasks increased resemblance to HC, reflecting the normalization of neural processes associated with silent object name retrieval. In contrast, connections that were specifically enhanced by the phonological condition in PWA decreased in their resemblance to HC, reflecting emerging compensatory reorganization in RH connectivity to support phonological processing. These findings suggest that both normalization and compensation play a role in neural language reorganization at the chronic stage, occurring simultaneously in the same brain. |
| first_indexed | 2024-03-10T06:41:03Z |
| format | Article |
| id | doaj.art-05775094519d44ee9efe959c6c3d38eb |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T06:41:03Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-05775094519d44ee9efe959c6c3d38eb2023-11-22T17:37:31ZengMDPI AGBrain Sciences2076-34252021-10-011110133010.3390/brainsci11101330Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia TherapyTammar Truzman0Elizabeth Rochon1Jed Meltzer2Carol Leonard3Tali Bitan4Communication Sciences and Disorders Department and IIPDM, University of Haifa, Haifa 3498838, IsraelDepartment of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, CanadaDepartment of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, CanadaDepartment of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, CanadaThe Integrated Brain and Behavior Research Center, University of Haifa, Haifa 3498838, IsraelChanges in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI scans were administered to all participants with a 3.5-month interval. The fMRI scans included phonological and semantic tasks, each consisting of linguistic and perceptual matching conditions. Between the two fMRI scans, PWA underwent Phonological Components Analysis treatment. Changes in effective connectivity during the treatment were examined within right hemisphere (RH) architecture. The results illustrate that following the treatment, the averaged connectivity of PWA across all perceptual and linguistic conditions in both tasks increased resemblance to HC, reflecting the normalization of neural processes associated with silent object name retrieval. In contrast, connections that were specifically enhanced by the phonological condition in PWA decreased in their resemblance to HC, reflecting emerging compensatory reorganization in RH connectivity to support phonological processing. These findings suggest that both normalization and compensation play a role in neural language reorganization at the chronic stage, occurring simultaneously in the same brain.https://www.mdpi.com/2076-3425/11/10/1330effective connectivitylanguage networkDCMPEBaphasiastroke |
| spellingShingle | Tammar Truzman Elizabeth Rochon Jed Meltzer Carol Leonard Tali Bitan Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy Brain Sciences effective connectivity language network DCM PEB aphasia stroke |
| title | Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy |
| title_full | Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy |
| title_fullStr | Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy |
| title_full_unstemmed | Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy |
| title_short | Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy |
| title_sort | simultaneous normalization and compensatory changes in right hemisphere connectivity during aphasia therapy |
| topic | effective connectivity language network DCM PEB aphasia stroke |
| url | https://www.mdpi.com/2076-3425/11/10/1330 |
| work_keys_str_mv | AT tammartruzman simultaneousnormalizationandcompensatorychangesinrighthemisphereconnectivityduringaphasiatherapy AT elizabethrochon simultaneousnormalizationandcompensatorychangesinrighthemisphereconnectivityduringaphasiatherapy AT jedmeltzer simultaneousnormalizationandcompensatorychangesinrighthemisphereconnectivityduringaphasiatherapy AT carolleonard simultaneousnormalizationandcompensatorychangesinrighthemisphereconnectivityduringaphasiatherapy AT talibitan simultaneousnormalizationandcompensatorychangesinrighthemisphereconnectivityduringaphasiatherapy |