APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations

APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations

Seizures are emerging as a common symptom in Alzheimer’s disease (AD) patients, often attributed to high levels of amyloid β (Aβ). However, the extent that AD disease risk factors modulate seizure activity in aging and AD-relevant contexts is unclear. APOE4 is the greatest genetic risk factor for AD...

Full description

Bibliographic Details
Main Authors: Lorissa Lamoureux, Felecia M. Marottoli, Kuei Y. Tseng, Leon M. Tai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
apolipoprotein E
seizure
amyloid beta
sex
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.656521/full

Similar Items

Similar Items