Pharmacological modulation of cell functional activity with valproic acid and erythropoietin
Introduction: Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug. Valproic acid influence on cells in vivo: VA, which is an antiepileptic drug, is also a teratogen, which causes defects of a neural tube and an axial skeleton, althou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Belgorod National Research University
2019-06-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/34710/download/pdf/ |
| _version_ | 1797431530680745984 |
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| author | Polina A. Golubinskaya Marina V. Sarycheva Svetlana Y. Burda Maksim V. Puzanov Natalya A. Nadezhdina Vladimir F. Kulikovskiy Sergey V. Nadezhdin Michail V. Korokin Yuriy E. Burda |
| author_facet | Polina A. Golubinskaya Marina V. Sarycheva Svetlana Y. Burda Maksim V. Puzanov Natalya A. Nadezhdina Vladimir F. Kulikovskiy Sergey V. Nadezhdin Michail V. Korokin Yuriy E. Burda |
| author_sort | Polina A. Golubinskaya |
| collection | DOAJ |
| description | Introduction: Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug.
Valproic acid influence on cells in vivo: VA, which is an antiepileptic drug, is also a teratogen, which causes defects of a neural tube and an axial skeleton, although the mechanisms are not yet fully clear.
Valproic acid influence on mesenchymal stem cells (MSC) in vitro: It is shown that valproic acid reduces the intracellular level of oxygen active forms.
Valproic acid effect on tumor cells: VA inhibits tumor growth through several mechanisms, including the cell cycle stop, differentiation induction and inhibition of growth of tumor vessels.
Valproic acid influence on enzymes: It affects mainly GSK-3.
Valproic acid influence on animals’ cells: It is shown that VA can significantly improve an ability to develop in vitro and improve nuclear reprogramming of embryos.
Erythropoietin (EPO): Is an hypoxia-induced hormone and a cytokine, which is necessary for normal erythropoiesis. EPO is widely used in in vitro experiments.
Conclusion: Thus, the influence of VA and EPO on cells can be used in cell technologies. |
| first_indexed | 2024-03-09T09:46:31Z |
| format | Article |
| id | doaj.art-05780fc184e347d88ad25f48b286bb0e |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:46:31Z |
| publishDate | 2019-06-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-05780fc184e347d88ad25f48b286bb0e2023-12-02T00:32:01ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2019-06-0152899910.3897/rrpharmacology.5.3471034710Pharmacological modulation of cell functional activity with valproic acid and erythropoietinPolina A. Golubinskaya0Marina V. Sarycheva1Svetlana Y. Burda2Maksim V. Puzanov3Natalya A. Nadezhdina4Vladimir F. Kulikovskiy5Sergey V. Nadezhdin6Michail V. Korokin7Yuriy E. Burda8Centre of Cell Technologies BiruchCentre of Cell Technologies BiruchVoronezh State Medical University named after N.N. BurdenkoCentre of Cell Technologies BiruchRegional Children's Clinical HospitalCentre of Cell Technologies BiruchCentre of Cell Technologies BiruchCentre of Cell Technologies BiruchCentre of Cell Technologies BiruchIntroduction: Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug. Valproic acid influence on cells in vivo: VA, which is an antiepileptic drug, is also a teratogen, which causes defects of a neural tube and an axial skeleton, although the mechanisms are not yet fully clear. Valproic acid influence on mesenchymal stem cells (MSC) in vitro: It is shown that valproic acid reduces the intracellular level of oxygen active forms. Valproic acid effect on tumor cells: VA inhibits tumor growth through several mechanisms, including the cell cycle stop, differentiation induction and inhibition of growth of tumor vessels. Valproic acid influence on enzymes: It affects mainly GSK-3. Valproic acid influence on animals’ cells: It is shown that VA can significantly improve an ability to develop in vitro and improve nuclear reprogramming of embryos. Erythropoietin (EPO): Is an hypoxia-induced hormone and a cytokine, which is necessary for normal erythropoiesis. EPO is widely used in in vitro experiments. Conclusion: Thus, the influence of VA and EPO on cells can be used in cell technologies.https://rrpharmacology.pensoft.net/article/34710/download/pdf/ |
| spellingShingle | Polina A. Golubinskaya Marina V. Sarycheva Svetlana Y. Burda Maksim V. Puzanov Natalya A. Nadezhdina Vladimir F. Kulikovskiy Sergey V. Nadezhdin Michail V. Korokin Yuriy E. Burda Pharmacological modulation of cell functional activity with valproic acid and erythropoietin Research Results in Pharmacology |
| title | Pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| title_full | Pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| title_fullStr | Pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| title_full_unstemmed | Pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| title_short | Pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| title_sort | pharmacological modulation of cell functional activity with valproic acid and erythropoietin |
| url | https://rrpharmacology.pensoft.net/article/34710/download/pdf/ |
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