Systemic signature of the lung response to respiratory syncytial virus infection.
Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3123345?pdf=render |
| _version_ | 1811191851946868736 |
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| author | Jeroen L A Pennings Annemieke Schuurhof Hennie M Hodemaekers Annemarie Buisman Lia C G H de Rond Myra N Widjojoatmodjo Willem Luytjes Jan L L Kimpen Louis Bont Riny Janssen |
| author_facet | Jeroen L A Pennings Annemieke Schuurhof Hennie M Hodemaekers Annemarie Buisman Lia C G H de Rond Myra N Widjojoatmodjo Willem Luytjes Jan L L Kimpen Louis Bont Riny Janssen |
| author_sort | Jeroen L A Pennings |
| collection | DOAJ |
| description | Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of acute infection, secondary immune response, and vaccine-enhanced disease, respectively. Eosinophil-associated ribonucleases were characteristic for the vaccine-enhanced disease blood signature. These results indicate that it may be possible to distinguish protective and unfavorable patient lung responses via blood diagnostics. |
| first_indexed | 2024-04-11T23:42:52Z |
| format | Article |
| id | doaj.art-05788a96c36945b7bbdb430076c1fd67 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:42:52Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-05788a96c36945b7bbdb430076c1fd672022-12-22T03:56:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2146110.1371/journal.pone.0021461Systemic signature of the lung response to respiratory syncytial virus infection.Jeroen L A PenningsAnnemieke SchuurhofHennie M HodemaekersAnnemarie BuismanLia C G H de RondMyra N WidjojoatmodjoWillem LuytjesJan L L KimpenLouis BontRiny JanssenRespiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of acute infection, secondary immune response, and vaccine-enhanced disease, respectively. Eosinophil-associated ribonucleases were characteristic for the vaccine-enhanced disease blood signature. These results indicate that it may be possible to distinguish protective and unfavorable patient lung responses via blood diagnostics.http://europepmc.org/articles/PMC3123345?pdf=render |
| spellingShingle | Jeroen L A Pennings Annemieke Schuurhof Hennie M Hodemaekers Annemarie Buisman Lia C G H de Rond Myra N Widjojoatmodjo Willem Luytjes Jan L L Kimpen Louis Bont Riny Janssen Systemic signature of the lung response to respiratory syncytial virus infection. PLoS ONE |
| title | Systemic signature of the lung response to respiratory syncytial virus infection. |
| title_full | Systemic signature of the lung response to respiratory syncytial virus infection. |
| title_fullStr | Systemic signature of the lung response to respiratory syncytial virus infection. |
| title_full_unstemmed | Systemic signature of the lung response to respiratory syncytial virus infection. |
| title_short | Systemic signature of the lung response to respiratory syncytial virus infection. |
| title_sort | systemic signature of the lung response to respiratory syncytial virus infection |
| url | http://europepmc.org/articles/PMC3123345?pdf=render |
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