Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan
The relationship between leptin and insulin resistance among middle-aged and elderly populations in Asia is seldom reported. Our research included 398 middle-aged and elderly Taiwanese individuals. First, we divided participants into three groups according to the tertiles of the homeostasis model as...
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/18/5357 |
| _version_ | 1797486608640901120 |
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| author | Yu-Lin Shih Tzu-Cheng Huang Chin-Chuan Shih Jau-Yuan Chen |
| author_facet | Yu-Lin Shih Tzu-Cheng Huang Chin-Chuan Shih Jau-Yuan Chen |
| author_sort | Yu-Lin Shih |
| collection | DOAJ |
| description | The relationship between leptin and insulin resistance among middle-aged and elderly populations in Asia is seldom reported. Our research included 398 middle-aged and elderly Taiwanese individuals. First, we divided participants into three groups according to the tertiles of the homeostasis model assessment of insulin resistance (HOMA-IR) to analyze the parameters between each group. Pearson’s correlation was then applied to calculate the correlation between HOMA-IR and cardiometabolic risk factors after adjusting for age. A scatter plot indicated a relationship between serum leptin levels and the HOMA-IR index. Finally, the coefficients of the serum leptin level and HOMA-IR were assessed by multivariate linear regression. The participants in the high HOMA-IR index group were more likely to have higher serum leptin levels. Meanwhile, the HOMA-IR index was positively correlated with serum leptin levels, even after adjusting for age. Serum leptin levels were positively correlated with the HOMA-IR index (β = 0.226, <i>p</i> < 0.01) in the multivariate linear regression after adjusting for age, sex, smoking, drinking, BMI, triglycerides, systolic blood pressure, fasting plasma glucose, uric acid, ALT, and creatinine. Furthermore, the leptin–creatinine ratio also showed a significantly positive relationship with HOMA-IR in the same multivariate linear regression model. In conclusion, serum leptin levels showed a positive relationship with insulin resistance in middle-aged and elderly people in Taiwan. Furthermore, serum leptin levels may be an independent risk factor for insulin resistance according to our study. |
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| format | Article |
| id | doaj.art-0579d92bb6f54ac380c1f65df50789db |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:36:38Z |
| publishDate | 2022-09-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-0579d92bb6f54ac380c1f65df50789db2023-11-23T16:59:23ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011118535710.3390/jcm11185357Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in TaiwanYu-Lin Shih0Tzu-Cheng Huang1Chin-Chuan Shih2Jau-Yuan Chen3Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanUnited Safety Medical Group, General Administrative Department, New Taipei City 242, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanThe relationship between leptin and insulin resistance among middle-aged and elderly populations in Asia is seldom reported. Our research included 398 middle-aged and elderly Taiwanese individuals. First, we divided participants into three groups according to the tertiles of the homeostasis model assessment of insulin resistance (HOMA-IR) to analyze the parameters between each group. Pearson’s correlation was then applied to calculate the correlation between HOMA-IR and cardiometabolic risk factors after adjusting for age. A scatter plot indicated a relationship between serum leptin levels and the HOMA-IR index. Finally, the coefficients of the serum leptin level and HOMA-IR were assessed by multivariate linear regression. The participants in the high HOMA-IR index group were more likely to have higher serum leptin levels. Meanwhile, the HOMA-IR index was positively correlated with serum leptin levels, even after adjusting for age. Serum leptin levels were positively correlated with the HOMA-IR index (β = 0.226, <i>p</i> < 0.01) in the multivariate linear regression after adjusting for age, sex, smoking, drinking, BMI, triglycerides, systolic blood pressure, fasting plasma glucose, uric acid, ALT, and creatinine. Furthermore, the leptin–creatinine ratio also showed a significantly positive relationship with HOMA-IR in the same multivariate linear regression model. In conclusion, serum leptin levels showed a positive relationship with insulin resistance in middle-aged and elderly people in Taiwan. Furthermore, serum leptin levels may be an independent risk factor for insulin resistance according to our study.https://www.mdpi.com/2077-0383/11/18/5357HOMA-IR indexinsulin resistanceleptinmiddle-aged and elderlymetabolic syndromeobesity |
| spellingShingle | Yu-Lin Shih Tzu-Cheng Huang Chin-Chuan Shih Jau-Yuan Chen Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan Journal of Clinical Medicine HOMA-IR index insulin resistance leptin middle-aged and elderly metabolic syndrome obesity |
| title | Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan |
| title_full | Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan |
| title_fullStr | Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan |
| title_full_unstemmed | Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan |
| title_short | Relationship between Leptin and Insulin Resistance among Community—Dwelling Middle-Aged and Elderly Populations in Taiwan |
| title_sort | relationship between leptin and insulin resistance among community dwelling middle aged and elderly populations in taiwan |
| topic | HOMA-IR index insulin resistance leptin middle-aged and elderly metabolic syndrome obesity |
| url | https://www.mdpi.com/2077-0383/11/18/5357 |
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