SGK1 in Cancer: Biomarker and Drug Target
Serum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2385 |
| _version_ | 1797501016029003776 |
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| author | Jonas Cicenas Edita Meskinyte-Kausiliene Vigilijus Jukna Arnas Rimkus Jokubas Simkus Diana Soderholm |
| author_facet | Jonas Cicenas Edita Meskinyte-Kausiliene Vigilijus Jukna Arnas Rimkus Jokubas Simkus Diana Soderholm |
| author_sort | Jonas Cicenas |
| collection | DOAJ |
| description | Serum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulated in some cancers and downregulated in others. SGK1 increases tumor cell survival, adhesiveness, invasiveness, motility, and epithelial to mesenchymal transition. It stimulates tumor growth by mechanisms such as activation of K<sup>+</sup> channels and Ca<sup>2+</sup> channels, Na<sup>+</sup>/H<sup>+</sup> exchanger, amino acid and glucose transporters, downregulation of Foxo3a and p53, and upregulation of β-catenin and NFκB. This chapter focuses on major aspects of SGK1 involvement in cancer, its use as biomarker as well as potential therapeutic target. |
| first_indexed | 2024-03-10T03:12:12Z |
| format | Article |
| id | doaj.art-057ad6207f6249d68a028894d62be54e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:12:12Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-057ad6207f6249d68a028894d62be54e2023-11-23T10:22:26ZengMDPI AGCancers2072-66942022-05-011410238510.3390/cancers14102385SGK1 in Cancer: Biomarker and Drug TargetJonas Cicenas0Edita Meskinyte-Kausiliene1Vigilijus Jukna2Arnas Rimkus3Jokubas Simkus4Diana Soderholm5Proteomics Centre, Institute of Biochemistry, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, LithuaniaCenter of Animal Husbandry Selections, Breeding Values and Dissemination, Agriculture Academy, Vytautas Magnus University, Studentų g. 11, LT-53361 Akademija, LithuaniaCenter of Animal Husbandry Selections, Breeding Values and Dissemination, Agriculture Academy, Vytautas Magnus University, Studentų g. 11, LT-53361 Akademija, LithuaniaMAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, CH-3027 Bern, SwitzerlandMAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, CH-3027 Bern, SwitzerlandWalker Art Center, 752 Vineland PI, Mineapolis, MN 55403, USASerum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulated in some cancers and downregulated in others. SGK1 increases tumor cell survival, adhesiveness, invasiveness, motility, and epithelial to mesenchymal transition. It stimulates tumor growth by mechanisms such as activation of K<sup>+</sup> channels and Ca<sup>2+</sup> channels, Na<sup>+</sup>/H<sup>+</sup> exchanger, amino acid and glucose transporters, downregulation of Foxo3a and p53, and upregulation of β-catenin and NFκB. This chapter focuses on major aspects of SGK1 involvement in cancer, its use as biomarker as well as potential therapeutic target.https://www.mdpi.com/2072-6694/14/10/2385SGK1SGK1 inhibitorscancerphosphorylationbiomarkerskinases |
| spellingShingle | Jonas Cicenas Edita Meskinyte-Kausiliene Vigilijus Jukna Arnas Rimkus Jokubas Simkus Diana Soderholm SGK1 in Cancer: Biomarker and Drug Target Cancers SGK1 SGK1 inhibitors cancer phosphorylation biomarkers kinases |
| title | SGK1 in Cancer: Biomarker and Drug Target |
| title_full | SGK1 in Cancer: Biomarker and Drug Target |
| title_fullStr | SGK1 in Cancer: Biomarker and Drug Target |
| title_full_unstemmed | SGK1 in Cancer: Biomarker and Drug Target |
| title_short | SGK1 in Cancer: Biomarker and Drug Target |
| title_sort | sgk1 in cancer biomarker and drug target |
| topic | SGK1 SGK1 inhibitors cancer phosphorylation biomarkers kinases |
| url | https://www.mdpi.com/2072-6694/14/10/2385 |
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