A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study
Abstract Background Treatment for locally advanced oesophagogastric adenocarcinoma involves neoadjuvant chemotherapy which has a negative impact on patient fitness. Using ‘prehabilitation’ to increase activity levels and fitness may affect physiology, postoperative outcomes and improve patient wellb...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
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| Series: | Pilot and Feasibility Studies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40814-022-01137-6 |
| _version_ | 1798042638657519616 |
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| author | Jakub Chmelo Alexander W. Phillips Alastair Greystoke Sarah J. Charman Leah Avery Kate Hallsworth Jenny Welford Matthew Cooper Rhona C. F. Sinclair |
| author_facet | Jakub Chmelo Alexander W. Phillips Alastair Greystoke Sarah J. Charman Leah Avery Kate Hallsworth Jenny Welford Matthew Cooper Rhona C. F. Sinclair |
| author_sort | Jakub Chmelo |
| collection | DOAJ |
| description | Abstract Background Treatment for locally advanced oesophagogastric adenocarcinoma involves neoadjuvant chemotherapy which has a negative impact on patient fitness. Using ‘prehabilitation’ to increase activity levels and fitness may affect physiology, postoperative outcomes and improve patient wellbeing and quality of life. The aims of the trial were to address the feasibility and acceptability of recruiting participants to a home-based prehabilitation programme and provide data to allow design of future studies. Methods We recruited patients to a single-arm feasibility trial of home-based exercise prehabilitation. Eligible patients were aged ≥18years, had operable oesophageal or gastric adenocarcinoma and were receiving neoadjuvant chemotherapy at our tertiary referral hospital. All participants commenced a home-based exercise programme utilising pedometers and step counting to target daily aerobic exercise sessions alongside daily strengthening exercises. A weekly telephone consultation directed the exercise programme and facilitated weekly data collection. The primary (feasibility) outcomes for the trial were (a) recruitment rate, (b) completion rate, (c) engagement with the programme (use of pedometers, recording step counts, telephone consultations) and (d) compliance with exercise sessions, exercise intensity and strengthening exercises. Results There were 42 patients recruited, and the recruitment rate was 72.4% (42/58). 92.3% (36/39) of patients completed the exercise programme. There was 98.7% (IQR 93.2–100.0%) compliance with wearing a pedometer and recording data, and 100.0% (IQR 93.1–100.0%) compliance with a weekly telephone consultation. Exercise sessions and strengthening exercises were completed 70.2% (IQR 53.1–88.9%) and 69.4% (IQR 52.1–84.3%) of the time, respectively. Appropriate exercise intensity was recorded 96% (IQR 85.4–99.4%) of the time. There were no adverse events. Participants were enrolled in the exercise programme for a median of 91 days (IQR 84 to 105 days). Conclusions The results of this trial support the feasibility and acceptability of recruiting participants to an appropriately powered randomised controlled trial of prehabilitation. Trial registration Clinicaltrials.gov NCT04194463 . Registered on 11th December 2019—retrospectively registered. |
| first_indexed | 2024-04-11T22:38:16Z |
| format | Article |
| id | doaj.art-057c6b302583472a9ec0ebd8c3d5c8df |
| institution | Directory Open Access Journal |
| issn | 2055-5784 |
| language | English |
| last_indexed | 2024-04-11T22:38:16Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Pilot and Feasibility Studies |
| spelling | doaj.art-057c6b302583472a9ec0ebd8c3d5c8df2022-12-22T03:59:06ZengBMCPilot and Feasibility Studies2055-57842022-08-018111010.1186/s40814-022-01137-6A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit studyJakub Chmelo0Alexander W. Phillips1Alastair Greystoke2Sarah J. Charman3Leah Avery4Kate Hallsworth5Jenny Welford6Matthew Cooper7Rhona C. F. Sinclair8Northern Oesophago-gastric unit, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation TrustNorthern Oesophago-gastric unit, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation TrustTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityNorthern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation TrustCentre for Rehabilitation, School of Health & Life Sciences, Teesside UniversityDepartment of Anaesthesia and Critical Care, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation TrustAbstract Background Treatment for locally advanced oesophagogastric adenocarcinoma involves neoadjuvant chemotherapy which has a negative impact on patient fitness. Using ‘prehabilitation’ to increase activity levels and fitness may affect physiology, postoperative outcomes and improve patient wellbeing and quality of life. The aims of the trial were to address the feasibility and acceptability of recruiting participants to a home-based prehabilitation programme and provide data to allow design of future studies. Methods We recruited patients to a single-arm feasibility trial of home-based exercise prehabilitation. Eligible patients were aged ≥18years, had operable oesophageal or gastric adenocarcinoma and were receiving neoadjuvant chemotherapy at our tertiary referral hospital. All participants commenced a home-based exercise programme utilising pedometers and step counting to target daily aerobic exercise sessions alongside daily strengthening exercises. A weekly telephone consultation directed the exercise programme and facilitated weekly data collection. The primary (feasibility) outcomes for the trial were (a) recruitment rate, (b) completion rate, (c) engagement with the programme (use of pedometers, recording step counts, telephone consultations) and (d) compliance with exercise sessions, exercise intensity and strengthening exercises. Results There were 42 patients recruited, and the recruitment rate was 72.4% (42/58). 92.3% (36/39) of patients completed the exercise programme. There was 98.7% (IQR 93.2–100.0%) compliance with wearing a pedometer and recording data, and 100.0% (IQR 93.1–100.0%) compliance with a weekly telephone consultation. Exercise sessions and strengthening exercises were completed 70.2% (IQR 53.1–88.9%) and 69.4% (IQR 52.1–84.3%) of the time, respectively. Appropriate exercise intensity was recorded 96% (IQR 85.4–99.4%) of the time. There were no adverse events. Participants were enrolled in the exercise programme for a median of 91 days (IQR 84 to 105 days). Conclusions The results of this trial support the feasibility and acceptability of recruiting participants to an appropriately powered randomised controlled trial of prehabilitation. Trial registration Clinicaltrials.gov NCT04194463 . Registered on 11th December 2019—retrospectively registered.https://doi.org/10.1186/s40814-022-01137-6PrehabilitationOesophagogastric cancerFeasibilitySurgical oncologyExerciseHome-based training |
| spellingShingle | Jakub Chmelo Alexander W. Phillips Alastair Greystoke Sarah J. Charman Leah Avery Kate Hallsworth Jenny Welford Matthew Cooper Rhona C. F. Sinclair A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study Pilot and Feasibility Studies Prehabilitation Oesophagogastric cancer Feasibility Surgical oncology Exercise Home-based training |
| title | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study |
| title_full | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study |
| title_fullStr | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study |
| title_full_unstemmed | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study |
| title_short | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study |
| title_sort | feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi component home based exercise programme the chemofit study |
| topic | Prehabilitation Oesophagogastric cancer Feasibility Surgical oncology Exercise Home-based training |
| url | https://doi.org/10.1186/s40814-022-01137-6 |
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