Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model

Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model

Phenol red (PR) is a widely used marker for water flux correction in studies of in situ perfusion, in which intestinal absorption usually leads to the underestimation of results. In this paper, we propose a novel marker polyethylene glycol (PEG)-PR (i.e., PR modified by PEGylation) with less permeab...

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Bibliographic Details
Main Authors: Guo Chen, Xingqi Min, Qunqun Zhang, Zhiqiang Zhang, Meiqiang Wen, Jun Yang, Meijuan Zou, Wei Sun, Gang Cheng
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
phenol red
water flux correction
PEGylation
permeability
everted gut sac (EGS)
in situ perfusion model
Online Access:https://www.mdpi.com/1420-3049/25/21/5123

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