Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis
Background: Psoriasis vulgaris (PV) is a longstanding, inflammatory, immune-responsive skin condition. Chinese herbal medicine injections (CHMIs) have been utilized for treating PV in Asian countries. This study aims to conduct a thorough systematic review and meta-analysis to comprehensively apprai...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1148445/full |
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| author | Ziqing Li Jie Lu Jiaxin Ou Jingjie Yu Jingjie Yu Chuanjian Lu Chuanjian Lu Chuanjian Lu |
| author_facet | Ziqing Li Jie Lu Jiaxin Ou Jingjie Yu Jingjie Yu Chuanjian Lu Chuanjian Lu Chuanjian Lu |
| author_sort | Ziqing Li |
| collection | DOAJ |
| description | Background: Psoriasis vulgaris (PV) is a longstanding, inflammatory, immune-responsive skin condition. Chinese herbal medicine injections (CHMIs) have been utilized for treating PV in Asian countries. This study aims to conduct a thorough systematic review and meta-analysis to comprehensively appraise the efficacy of CHMIs in treating PV.Methods: Seven databases were searched for randomized controlled trials that evaluated the effect of CHMIs in treating PV, ranging from 2004 to June 2022. The meta-analysis was undertaken based on outcome measures, treatment options, and treatment durations using Review Manager 5.4. The primary outcome measure of this study was a 60% or higher reduction in the Psoriasis Area and Severity Index score (PASI 60). A descriptive analysis was performed for the assessment of adverse events.Results: This systematic review incorporated 33 studies, comprising 3,059 participants. The main findings indicated significant differences based on the PASI 60 (RR = 1.30, 95% CI: 1.24 to 1.37, Z = 10.72, p < 0.00001), PASI 30 (RR = 1.25, 95% CI: 1.13 to 1.38, Z = 4.48, p < 0.00001), and PASI 20 (RR = 1.28, 95% CI: 1.13 to 1.45, Z = 3.82, p = 0.0001) outcome measures. Evaluating the treatment options, CHMIs in combination with monotherapies like narrowband ultraviolet B (NB-UVB) and the acitretin capsule (AC) showed a greater reduction in PASI 60 (RR = 1.33, 95% CI: 1.25 to 1.43, Z = 8.32, p < 0.00001). In terms of treatment duration, no significant difference was observed when the duration extended beyond 56 days. Furthermore, the results suggested that CHMIs might reduce the incidence of adverse events in the treatment of PV.Conclusion: This systematic review revealed preliminary clinical evidence supporting the use of CHMIs for treating PV, considering outcome measures, treatment options, and treatment durations. However, due to the low methodological quality and limited sample size of the included studies, there is an urgent need for high-quality, multi-center and larger-scale studies of CHMIs for PV to provide robust evidence for their clinical application.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=326531], identifier [CRD42022326531]. |
| first_indexed | 2024-03-13T01:46:13Z |
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| id | doaj.art-05805f7313c947499bcebd05420c1d20 |
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| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T01:46:13Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-05805f7313c947499bcebd05420c1d202023-07-03T07:44:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-07-011410.3389/fphar.2023.11484451148445Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysisZiqing Li0Jie Lu1Jiaxin Ou2Jingjie Yu3Jingjie Yu4Chuanjian Lu5Chuanjian Lu6Chuanjian Lu7The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, ChinaThe Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research and Guangdong Provincial Key Laboratory of Clinical Research on Chinese Medicine Syndrome, Guangzhou, Guangdong, ChinaBackground: Psoriasis vulgaris (PV) is a longstanding, inflammatory, immune-responsive skin condition. Chinese herbal medicine injections (CHMIs) have been utilized for treating PV in Asian countries. This study aims to conduct a thorough systematic review and meta-analysis to comprehensively appraise the efficacy of CHMIs in treating PV.Methods: Seven databases were searched for randomized controlled trials that evaluated the effect of CHMIs in treating PV, ranging from 2004 to June 2022. The meta-analysis was undertaken based on outcome measures, treatment options, and treatment durations using Review Manager 5.4. The primary outcome measure of this study was a 60% or higher reduction in the Psoriasis Area and Severity Index score (PASI 60). A descriptive analysis was performed for the assessment of adverse events.Results: This systematic review incorporated 33 studies, comprising 3,059 participants. The main findings indicated significant differences based on the PASI 60 (RR = 1.30, 95% CI: 1.24 to 1.37, Z = 10.72, p < 0.00001), PASI 30 (RR = 1.25, 95% CI: 1.13 to 1.38, Z = 4.48, p < 0.00001), and PASI 20 (RR = 1.28, 95% CI: 1.13 to 1.45, Z = 3.82, p = 0.0001) outcome measures. Evaluating the treatment options, CHMIs in combination with monotherapies like narrowband ultraviolet B (NB-UVB) and the acitretin capsule (AC) showed a greater reduction in PASI 60 (RR = 1.33, 95% CI: 1.25 to 1.43, Z = 8.32, p < 0.00001). In terms of treatment duration, no significant difference was observed when the duration extended beyond 56 days. Furthermore, the results suggested that CHMIs might reduce the incidence of adverse events in the treatment of PV.Conclusion: This systematic review revealed preliminary clinical evidence supporting the use of CHMIs for treating PV, considering outcome measures, treatment options, and treatment durations. However, due to the low methodological quality and limited sample size of the included studies, there is an urgent need for high-quality, multi-center and larger-scale studies of CHMIs for PV to provide robust evidence for their clinical application.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=326531], identifier [CRD42022326531].https://www.frontiersin.org/articles/10.3389/fphar.2023.1148445/fullChinese herbal medicine injectionspsoriasis vulgarissystematic reviewmeta-analysisrandomized controlled trial |
| spellingShingle | Ziqing Li Jie Lu Jiaxin Ou Jingjie Yu Jingjie Yu Chuanjian Lu Chuanjian Lu Chuanjian Lu Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis Frontiers in Pharmacology Chinese herbal medicine injections psoriasis vulgaris systematic review meta-analysis randomized controlled trial |
| title | Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis |
| title_full | Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis |
| title_fullStr | Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis |
| title_short | Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis |
| title_sort | effect of chinese herbal medicine injections for treatment of psoriasis vulgaris a systematic review and meta analysis |
| topic | Chinese herbal medicine injections psoriasis vulgaris systematic review meta-analysis randomized controlled trial |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1148445/full |
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