A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile

A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile

Antibiotics are considered to be the first line of treatment for mild to moderately severe Clostridium difficile infection (CDI) in humans. However, antibiotics are also risk factors for CDI as they decrease colonization resistance against C. difficile by altering the gut microbiota and metabolome....

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Bibliographic Details
Main Authors: Rajani Thanissery, Daina Zeng, Raul G. Doyle, Casey M. Theriot
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
C. difficile
small molecules
2-aminoimidazole
growth
toxin
sporulation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01206/full

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