The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer
Background: Basic leucine zipper and W2 domains 2 (BZW2), a member of the basic domain leucine zipper superfamily of transcription factors, has been implicated in the development and progression of various cancers. However, the precise biological role of BZW2 in pan-cancer datasets remains to be exp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2024-03-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/29/3/10.31083/j.fbl2903097 |
| _version_ | 1797238591720521728 |
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| author | Chaolin Li Qin Li Li Li Siyu Sun Xun Lei |
| author_facet | Chaolin Li Qin Li Li Li Siyu Sun Xun Lei |
| author_sort | Chaolin Li |
| collection | DOAJ |
| description | Background: Basic leucine zipper and W2 domains 2 (BZW2), a member of the basic domain leucine zipper superfamily of transcription factors, has been implicated in the development and progression of various cancers. However, the precise biological role of BZW2 in pan-cancer datasets remains to be explored. This study aimed to assess the prognostic significance of BZW2 and its immune-related signatures in various tumors. Methods: Our study investigated the expression, epigenetic modifications, and clinical prognostic relevance of BZW2 using multi-omics data in different cancer types. Additionally, the immunological characteristics, tumor stemness, drug sensitivity, and correlation of BZW2 with immunotherapy response were explored. Finally, in vitro experiments were conducted to assess the impact of BZW2 knockdown on Hela cells, a cell line derived from cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Results: BZW2 exhibited elevated expression levels in various tumor tissues and significantly impacted the prognosis of different cancer types. BZW2 emerged as an independent prognostic factor in CESC. We found that copy number amplification and methylation levels of BZW2 were associated with its mRNA expression. Immunological analyses revealed that BZW2 shapes a non-inflamed immunosuppressive tumor microenvironment across multiple cancers. Furthermore, our cell experiments demonstrated that BZW2 knockdown reduced proliferation, migration, and apoptosis activities in CESC cells. Conclusions: BZW2 promotes cancer progression by shaping a non-inflamed immunosuppressive tumor microenvironment. Additionally, BZW2 was shown to significantly influence the proliferation, migration, and apoptosis of CESC cells. |
| first_indexed | 2024-04-24T17:38:05Z |
| format | Article |
| id | doaj.art-0584e924a743433e8f6f260e2d2691d5 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-24T17:38:05Z |
| publishDate | 2024-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-0584e924a743433e8f6f260e2d2691d52024-03-28T02:27:54ZengIMR PressFrontiers in Bioscience-Landmark2768-67012024-03-012939710.31083/j.fbl2903097S2768-6701(23)01176-0The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical CancerChaolin Li0Qin Li1Li Li2Siyu Sun3Xun Lei4Jinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, ChinaJinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, ChinaJinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, ChinaJinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, ChinaJinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, ChinaBackground: Basic leucine zipper and W2 domains 2 (BZW2), a member of the basic domain leucine zipper superfamily of transcription factors, has been implicated in the development and progression of various cancers. However, the precise biological role of BZW2 in pan-cancer datasets remains to be explored. This study aimed to assess the prognostic significance of BZW2 and its immune-related signatures in various tumors. Methods: Our study investigated the expression, epigenetic modifications, and clinical prognostic relevance of BZW2 using multi-omics data in different cancer types. Additionally, the immunological characteristics, tumor stemness, drug sensitivity, and correlation of BZW2 with immunotherapy response were explored. Finally, in vitro experiments were conducted to assess the impact of BZW2 knockdown on Hela cells, a cell line derived from cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Results: BZW2 exhibited elevated expression levels in various tumor tissues and significantly impacted the prognosis of different cancer types. BZW2 emerged as an independent prognostic factor in CESC. We found that copy number amplification and methylation levels of BZW2 were associated with its mRNA expression. Immunological analyses revealed that BZW2 shapes a non-inflamed immunosuppressive tumor microenvironment across multiple cancers. Furthermore, our cell experiments demonstrated that BZW2 knockdown reduced proliferation, migration, and apoptosis activities in CESC cells. Conclusions: BZW2 promotes cancer progression by shaping a non-inflamed immunosuppressive tumor microenvironment. Additionally, BZW2 was shown to significantly influence the proliferation, migration, and apoptosis of CESC cells.https://www.imrpress.com/journal/FBL/29/3/10.31083/j.fbl2903097bzw2cescimmunity therapyapoptosisbiomarkers |
| spellingShingle | Chaolin Li Qin Li Li Li Siyu Sun Xun Lei The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer Frontiers in Bioscience-Landmark bzw2 cesc immunity therapy apoptosis biomarkers |
| title | The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer |
| title_full | The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer |
| title_fullStr | The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer |
| title_full_unstemmed | The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer |
| title_short | The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer |
| title_sort | prognostic and immune significance of bzw2 in pan cancer and its relationship with proliferation and apoptosis of cervical cancer |
| topic | bzw2 cesc immunity therapy apoptosis biomarkers |
| url | https://www.imrpress.com/journal/FBL/29/3/10.31083/j.fbl2903097 |
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