Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Increasing extracellular osmolarity 100 mOsm/kg above plasma level to the physiological levels for cartilage induces chondrogenic marker expression and the differentiation of chondroprogenitor cells. The calcineurin inhibitor FK506 has been reported to modulate the hypertrophic differentiation of pr...

Full description

Bibliographic Details
Main Authors:	Holger Jahr, Anna E. van der Windt, Ufuk Tan Timur, Esther B. Baart, Wei-Shiung Lian, Bernd Rolauffs, Feng-Sheng Wang, Thomas Pufe
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	hyperosmolarity chondrocyte differentiation ATDC5 FK506 calcineurin
Online Access:	https://www.mdpi.com/1422-0067/23/9/5110

Similar Items

Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium
by: Li Wang, et al.
Published: (2017-02-01)

Harnessing IGF-1 and IL-2 as biomarkers for calcineurin activity to tailor optimal FK506 dosage in α-synucleinopathies
by: Sofia Zaichick, et al.
Published: (2023-11-01)

Therapeutic Effects of FK506 on IgA Nephropathy Rat
by: Linting Wei, et al.
Published: (2017-11-01)

Tacrolimus (FK506) Exhibits Fungicidal Effects against <i>Candida parapsilosis</i> Sensu Stricto via Inducing Apoptosis
by: Otomi Cho, et al.
Published: (2023-07-01)

Rapid Improvement of Genital Aphthae by Topical FK-506 in
by: Mansoor Karimifar, et al.
Published: (2011-03-01)

The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats
by: Jinzhi Liu, et al.
Published: (2018-01-01)

Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm
by: Amirmasoud Hadjiasgary, et al.
Published: (2015-02-01)

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice
by: Anete Rozkalne, et al.
Published: (2011-03-01)

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model
by: Ali AS, et al.
Published: (2020-10-01)

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
by: Jun Ge, et al.
Published: (2020-12-01)

Study on the Effect of Immunosuppressive Agent FK506 on Growth and Migration of Lung Cancer Cell
by: Yongwen LI, et al.
Published: (2017-06-01)

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model [Corrigendum]
by: Ali AS, et al.
Published: (2023-01-01)

Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes
by: Giulia Dematteis, et al.
Published: (2022-02-01)

FK506 biosynthesis is regulated by two positive regulatory elements in <it>Streptomyces tsukubaensis</it>
by: Goranovič Dušan, et al.
Published: (2012-10-01)

Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis
by: Susann Schulz, et al.
Published: (2022-11-01)

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats
by: Aihua Wang, et al.
Published: (2019-09-01)

Injectable thermosensitive hydrogel loading erythropoietin and FK506 alleviates gingival inflammation and promotes periodontal tissue regeneration
by: Zhongyi Gu, et al.
Published: (2024-01-01)

Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection
by: Cheng Deng, et al.
Published: (2023-11-01)

Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506)
by: Simeon C. Daeschler, et al.
Published: (2023-08-01)

Calcineurin B inhibits calcium oxalate crystallization, growth and aggregation via its high calcium-affinity property
by: Sudarat Hadpech, et al.
Published: (2023-01-01)

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo
by: Dana E Orange, et al.
Published: (2013-02-01)

Protective effect of FK506 combined with hypothermic mechanical perfusion on donor liver of rats
by: JIANG Li, LI Jian-hui, YU Hao, LI Hao-yu, XIE Hai-yang, ZHOU Lin, ZHENG Shu-sen
Published: (2021-12-01)

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen <i>Aspergillus fumigatus</i>
by: Praveen R. Juvvadi, et al.
Published: (2022-12-01)

Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study
by: F. Giordani, et al.
Published: (2003-04-01)

Controlled release of FK506 from micropatterned PLGA films: potential for application in peripheral nerve repair
by: Brett Davis, et al.
Published: (2018-01-01)

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye
by: Yi Han, et al.
Published: (2022-03-01)

Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
by: Nancy R. Stallings, et al.
Published: (2023-10-01)

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake
by: Shikshya Shrestha, et al.
Published: (2020-07-01)

Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients
by: Charat Thongprayoon, et al.
Published: (2020-07-01)

Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin
by: Rajan, Sreekanth, et al.
Published: (2018)

Treatment With Nimodipine or FK506 After Facial Nerve Repair Neither Improves Accuracy of Reinnervation Nor Recovery of Mimetic Function in Rats
by: Mohammed Barham, et al.
Published: (2022-05-01)

Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis
by: Qing-Bin Wu, et al.
Published: (2021-08-01)

Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress
by: Anantika Suri, et al.
Published: (2022-12-01)

Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency
by: Eun Hee Ahn, et al.
Published: (2013-11-01)

Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury
by: Rubèn López-Vales, et al.
Published: (2006-12-01)

The effect of FK506 (tacrolimus) loaded with collagen membrane and fibrin glue on promotion of nerve regeneration in a rat sciatic nerve traction injury model
by: Jin-Hong Kim, et al.
Published: (2022-04-01)

Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model
by: Dae Won Kim, et al.
Published: (2013-02-01)

Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy
by: Nahide Ekici Günay, et al.
Published: (2018-03-01)

FK506 and Lactobacillus acidophilus ameliorate acute graft-versus-host disease by modulating the T helper 17/regulatory T-cell balance
by: Jin-Ah Beak, et al.
Published: (2022-02-01)

Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin
by: Katharina Ernst, et al.
Published: (2018-11-01)