A thermophilic 8-oxoguanine DNA glycosylase from Thermococcus barophiluss Ch5 is a new member of AGOG DNA glycosylase family

A thermophilic 8-oxoguanine DNA glycosylase from Thermococcus barophiluss Ch5 is a new member of AGOG DNA glycosylase family

<?A3B2 tlsb=-.002w?>8-Oxoguanine (8oxoG) in DNA is a major oxidized base that poses a severe threat to genome stability. To counteract the mutagenic effect generated by 8oxoG in DNA, cells have evolved 8oxoG DNA glycosylase (OGG) that can excise this oxidized base from DNA. Currently, OGG enzy...

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Bibliographic Details
Main Authors: Wang Lei, Jiang Donghao, Zhang Likui
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-06-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
hyperthermophilic Archaea
8-oxoguanine
8oxoG DNA glycosylase
biochemical characteristic
base excision repair
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022072

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