Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype
Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/8032 |
| _version_ | 1797406077927555072 |
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| author | Junhu Tai Jiwon Kwak Munsoo Han Tae Hoon Kim |
| author_facet | Junhu Tai Jiwon Kwak Munsoo Han Tae Hoon Kim |
| author_sort | Junhu Tai |
| collection | DOAJ |
| description | Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed. |
| first_indexed | 2024-03-09T03:20:00Z |
| format | Article |
| id | doaj.art-0586c2a41cbb48c190f1aff6a4503b54 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:20:00Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0586c2a41cbb48c190f1aff6a4503b542023-12-03T15:10:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314803210.3390/ijms23148032Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to PhenotypeJunhu Tai0Jiwon Kwak1Munsoo Han2Tae Hoon Kim3Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.https://www.mdpi.com/1422-0067/23/14/8032chronic rhinosinusitisdendritic cellsimmunityphenotype |
| spellingShingle | Junhu Tai Jiwon Kwak Munsoo Han Tae Hoon Kim Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype International Journal of Molecular Sciences chronic rhinosinusitis dendritic cells immunity phenotype |
| title | Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype |
| title_full | Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype |
| title_fullStr | Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype |
| title_full_unstemmed | Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype |
| title_short | Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype |
| title_sort | different roles of dendritic cells for chronic rhinosinusitis treatment according to phenotype |
| topic | chronic rhinosinusitis dendritic cells immunity phenotype |
| url | https://www.mdpi.com/1422-0067/23/14/8032 |
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