Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer
Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/1/67 |
| _version_ | 1797446801538678784 |
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| author | Ali A. Akhiani Anna Martner |
| author_facet | Ali A. Akhiani Anna Martner |
| author_sort | Ali A. Akhiani |
| collection | DOAJ |
| description | Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer. |
| first_indexed | 2024-03-09T13:46:47Z |
| format | Article |
| id | doaj.art-058748c6a6d64e4cad3e78291094d98a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:46:47Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-058748c6a6d64e4cad3e78291094d98a2023-11-30T20:57:52ZengMDPI AGAntioxidants2076-39212022-12-011216710.3390/antiox12010067Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in CancerAli A. Akhiani0Anna Martner1Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, SwedenActivation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.https://www.mdpi.com/2076-3921/12/1/67NOXreactive oxygen speciesPI3K pathwaycancer |
| spellingShingle | Ali A. Akhiani Anna Martner Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer Antioxidants NOX reactive oxygen species PI3K pathway cancer |
| title | Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer |
| title_full | Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer |
| title_fullStr | Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer |
| title_full_unstemmed | Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer |
| title_short | Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer |
| title_sort | role of phosphoinositide 3 kinase in regulation of nox derived reactive oxygen species in cancer |
| topic | NOX reactive oxygen species PI3K pathway cancer |
| url | https://www.mdpi.com/2076-3921/12/1/67 |
| work_keys_str_mv | AT aliaakhiani roleofphosphoinositide3kinaseinregulationofnoxderivedreactiveoxygenspeciesincancer AT annamartner roleofphosphoinositide3kinaseinregulationofnoxderivedreactiveoxygenspeciesincancer |