Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the sto...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300015 |
| _version_ | 1797756747184603136 |
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| author | Lucas Trevizani Rasmussen Roger William de Labio Luciano Lobo Gatti Luiz Carlos da Silva Valdeir Fagundes de Queiroz Marília de Arruda Cardoso Smith Spencer Luiz Marques Payão |
| author_facet | Lucas Trevizani Rasmussen Roger William de Labio Luciano Lobo Gatti Luiz Carlos da Silva Valdeir Fagundes de Queiroz Marília de Arruda Cardoso Smith Spencer Luiz Marques Payão |
| author_sort | Lucas Trevizani Rasmussen |
| collection | DOAJ |
| description | Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection. |
| first_indexed | 2024-03-12T18:05:01Z |
| format | Article |
| id | doaj.art-058884108dbe4af9934164f88f19262c |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:01Z |
| publishDate | 2010-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-058884108dbe4af9934164f88f19262c2023-08-02T09:28:27ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-05-01105332633010.1590/S0074-02762010000300015Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patientsLucas Trevizani RasmussenRoger William de LabioLuciano Lobo GattiLuiz Carlos da SilvaValdeir Fagundes de QueirozMarília de Arruda Cardoso SmithSpencer Luiz Marques PayãoHelicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300015Helicobacter pylorioral infectionsalivadental plaque |
| spellingShingle | Lucas Trevizani Rasmussen Roger William de Labio Luciano Lobo Gatti Luiz Carlos da Silva Valdeir Fagundes de Queiroz Marília de Arruda Cardoso Smith Spencer Luiz Marques Payão Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients Memorias do Instituto Oswaldo Cruz Helicobacter pylori oral infection saliva dental plaque |
| title | Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients |
| title_full | Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients |
| title_fullStr | Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients |
| title_full_unstemmed | Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients |
| title_short | Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients |
| title_sort | helicobacter pylori detection in gastric biopsies saliva and dental plaque of brazilian dyspeptic patients |
| topic | Helicobacter pylori oral infection saliva dental plaque |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300015 |
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