Protracted neuronal maturation in a long-lived, highly social rodent.
Naked mole-rats are a long-lived rodent species (current lifespan >37 years) and an increasingly popular biomedical model. Naked mole-rats exhibit neuroplasticity across their long lifespan. Previous studies have begun to investigate their neurogenic patterns. Here, we test the hypothesis that ne...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0273098 |
| _version_ | 1828111779403661312 |
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| author | Mariela Faykoo-Martinez Troy Collins Diana Peragine Manahil Malik Fiza Javed Matthew Kolisnyk Justine Ziolkowski Imaan Jeewa Arthur H Cheng Christopher Lowden Brittany Mascarenhas Hai-Ying Mary Cheng Melissa M Holmes |
| author_facet | Mariela Faykoo-Martinez Troy Collins Diana Peragine Manahil Malik Fiza Javed Matthew Kolisnyk Justine Ziolkowski Imaan Jeewa Arthur H Cheng Christopher Lowden Brittany Mascarenhas Hai-Ying Mary Cheng Melissa M Holmes |
| author_sort | Mariela Faykoo-Martinez |
| collection | DOAJ |
| description | Naked mole-rats are a long-lived rodent species (current lifespan >37 years) and an increasingly popular biomedical model. Naked mole-rats exhibit neuroplasticity across their long lifespan. Previous studies have begun to investigate their neurogenic patterns. Here, we test the hypothesis that neuronal maturation is extended in this long-lived rodent. We characterize cell proliferation and neuronal maturation in established rodent neurogenic regions over 12 months following seven days of consecutive BrdU injection. Given that naked mole-rats are eusocial (high reproductive skew where only a few socially-dominant individuals reproduce), we also looked at proliferation in brain regions relevant to the social-decision making network. Finally, we measured co-expression of EdU (newly-born cells), DCX (immature neuron marker), and NeuN (mature neuron marker) to assess the timeline of neuronal maturation in adult naked mole-rats. This work reaffirms the subventricular zone as the main source of adult cell proliferation and suggests conservation of the rostral migratory stream in this species. Our profiling of socially-relevant brain regions suggests that future work which manipulates environmental context can unveil how newly-born cells integrate into circuitry and facilitate adult neuroplasticity. We also find naked mole-rat neuronal maturation sits at the intersection of rodents and long-lived, non-rodent species: while neurons can mature by 3 weeks (rodent-like), most neurons mature at 5 months and hippocampal neurogenic levels are low (like long-lived species). These data establish a timeline for future investigations of longevity- and socially-related manipulations of naked mole-rat adult neurogenesis. |
| first_indexed | 2024-04-11T11:40:44Z |
| format | Article |
| id | doaj.art-058917493d0d43b69d09e6f8e86fef00 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T11:40:44Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-058917493d0d43b69d09e6f8e86fef002022-12-22T04:25:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027309810.1371/journal.pone.0273098Protracted neuronal maturation in a long-lived, highly social rodent.Mariela Faykoo-MartinezTroy CollinsDiana PeragineManahil MalikFiza JavedMatthew KolisnykJustine ZiolkowskiImaan JeewaArthur H ChengChristopher LowdenBrittany MascarenhasHai-Ying Mary ChengMelissa M HolmesNaked mole-rats are a long-lived rodent species (current lifespan >37 years) and an increasingly popular biomedical model. Naked mole-rats exhibit neuroplasticity across their long lifespan. Previous studies have begun to investigate their neurogenic patterns. Here, we test the hypothesis that neuronal maturation is extended in this long-lived rodent. We characterize cell proliferation and neuronal maturation in established rodent neurogenic regions over 12 months following seven days of consecutive BrdU injection. Given that naked mole-rats are eusocial (high reproductive skew where only a few socially-dominant individuals reproduce), we also looked at proliferation in brain regions relevant to the social-decision making network. Finally, we measured co-expression of EdU (newly-born cells), DCX (immature neuron marker), and NeuN (mature neuron marker) to assess the timeline of neuronal maturation in adult naked mole-rats. This work reaffirms the subventricular zone as the main source of adult cell proliferation and suggests conservation of the rostral migratory stream in this species. Our profiling of socially-relevant brain regions suggests that future work which manipulates environmental context can unveil how newly-born cells integrate into circuitry and facilitate adult neuroplasticity. We also find naked mole-rat neuronal maturation sits at the intersection of rodents and long-lived, non-rodent species: while neurons can mature by 3 weeks (rodent-like), most neurons mature at 5 months and hippocampal neurogenic levels are low (like long-lived species). These data establish a timeline for future investigations of longevity- and socially-related manipulations of naked mole-rat adult neurogenesis.https://doi.org/10.1371/journal.pone.0273098 |
| spellingShingle | Mariela Faykoo-Martinez Troy Collins Diana Peragine Manahil Malik Fiza Javed Matthew Kolisnyk Justine Ziolkowski Imaan Jeewa Arthur H Cheng Christopher Lowden Brittany Mascarenhas Hai-Ying Mary Cheng Melissa M Holmes Protracted neuronal maturation in a long-lived, highly social rodent. PLoS ONE |
| title | Protracted neuronal maturation in a long-lived, highly social rodent. |
| title_full | Protracted neuronal maturation in a long-lived, highly social rodent. |
| title_fullStr | Protracted neuronal maturation in a long-lived, highly social rodent. |
| title_full_unstemmed | Protracted neuronal maturation in a long-lived, highly social rodent. |
| title_short | Protracted neuronal maturation in a long-lived, highly social rodent. |
| title_sort | protracted neuronal maturation in a long lived highly social rodent |
| url | https://doi.org/10.1371/journal.pone.0273098 |
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